1452593-18-8Relevant articles and documents
Fine tuning of the pH-dependent drug release rate from polyHPMA- ellipticinium conjugates
Sedlá?ek, Ond?ej,Studenovsky, Martin,Větvi?ka, David,Ulbrich, Karel,Hruby, Martin
supporting information, p. 5669 - 5672 (2013/09/12)
Polymer conjugates of anticancer drugs have shown high potential for assisting in cancer treatments. The pH-labile spacers allow site-specific triggered release of the drugs. We synthesized and characterized model drug conjugates with hydrazide bond-containing poly[N-(2-hydroxypropyl) methacrylamide] differing in the chemical surrounding of the hydrazone bond-containing spacer to find structure-drug release rate relationships. The conjugate selected for further studies shows negligible drug release in a pH 7.4 buffer but released 50% of the ellipticinium drug within 24 h in a pH 5.0 phosphate saline buffer. The ellipticinium drug retained the antiproliferative activity of the ellipticine.
