145299-84-9

Basic information

• Product Name: 1,1-difluoro-4-phenyl-butan-2-one
• Synonyms: 1,1-difluoro-4-phenyl-butan-2-one
• CAS NO: 145299-84-9
• Molecular Weight: 184.186
• Mol File: 145299-84-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1,1-difluoro-4-phenyl-butan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-difluoro-4-phenyl-butan-2-one(145299-84-9)
• EPA Substance Registry System: 1,1-difluoro-4-phenyl-butan-2-one(145299-84-9)

Safety Data

• Hazardous Substances Data: 145299-84-9(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Slightly sweet and fruity

Applications

a. Synthesis of pharmaceuticals
b. Synthesis of agrochemicals
c. Building block in organic chemistry
d. Flavoring agent in the food industry

Health hazards

a. Eye irritation
b. Skin irritation
c. Respiratory system irritation

Safety concerns

Flammability

Handling precautions

Handle with care due to potential health hazards and flammability

Upstream product

• 65864-64-4 trimethyl(difluoromethyl)silane 
• 170646-96-5 N-methoxy-N-methyl-3-phenylpropionamide 
• 80783-99-9 N-methoxy-N-methylcinnamamide 
• 102-92-1 Cinnamoyl chloride 
• 1338328-42-9 4,4,6,6,6-pentafluoro-5,5-dihydroxy-1-phenylhexan-3-one 
• 454-31-9 ethyl difluoroacetate 
• 103-63-9 1-phenyl-2-bromoethane 
• 645-45-4 hydrocinnamic acid chloride 
• 3277-89-2 phenethylmagnesium bromide 

Downstream Products

• 1541177-55-2 1,1-difluoro-4-phenyl-2-((trimethylsilyl)methyl)butan-2-ol 
• 123986-77-6 (R)-1,1-Difluoro-4-phenyl-butan-2-ol 
• 123986-77-6 (S)-1,1-Difluoro-4-phenyl-butan-2-ol 
• 119454-43-2 Acetic acid 1-difluoromethyl-3-phenyl-propyl ester 
• 123986-77-6 1,1-difluoro-4-phenylbutan-2-ol 

Relevant articles and documents

Synthesis of Difluoromethyl Ketones from Weinreb Amides, and Tandem Addition/Cyclization of o-Alkynylaryl Weinreb Amides

[Difluoro(phenylsulfanyl)methyl]trimethylsilane (PhSCF2SiMe3) underwent a fluoride-induced nucleophilic addition to the carbonyl group of Weinreb amides to provide the corresponding difluoro(phenylsulfanyl)methyl ketones. These were

Biocatalytic Strategy for the Highly Stereoselective Synthesis of CHF2-Containing Trisubstituted Cyclopropanes

The difluoromethyl (CHF2) group has attracted significant attention in drug discovery and development efforts, owing to its ability to serve as fluorinated bioisostere of methyl, hydroxyl, and thiol groups. Herein, we report an efficient biocat

Well-Defined, Shelf-Stable (NHC)Ag(CF2H) Complexes for Difluoromethylation

The preparation of the thermally stable, well-defined NHC-ligated difluoromethylated silver complexes 1a,b is described. The complexes were fully characterized, and the structural assignments were ambiguously further confirmed by single-crystal X-ray diffraction. Reactions of [(SIPr)Ag(CF2H)] with a variety of activated electrophiles such as diaryliodonium salts, vinyl(aryl)iodonium salts, aryldiazonium salts, and acid chlorides in the presence or absence of CuI occurred smoothly at room temperature to generate difluoromethylated compounds in good to excellent yields. (Chemical Equation Presented).