145345-82-0

Basic information

• Product Name: C₄₈H₅₇NO₁₂
• CAS NO: 145345-82-0
• Molecular Weight: 839.98
• Mol File: 145345-82-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₈H₅₇NO₁₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₈H₅₇NO₁₂(145345-82-0)
• EPA Substance Registry System: C₄₈H₅₇NO₁₂(145345-82-0)

Safety Data

• Hazardous Substances Data: 145345-82-0(Hazardous Substances Data)

Upstream product

• 144879-84-5 evomonoside α-L-rhamnopyranoside tribenzoate 
• 75-52-5 nitromethane 
• 145345-70-6 14-hydroxy-3β-<(tri-O-benzoyl-α-L-rhamnopyranosyl)oxy>-21-nor-5β,14β-pregnane-20-carboxaldehyde 

Relevant articles and documents

Synthesis of 20-hydroxy-, 20-amino-, and 20-nitro-14-hydroxy-21-nor- 5β,14β-pregnane C-3 glycosides and related derivatives: Structure-activity relationships of pregnanes that bind to the digitalis receptor

The preparation of derivatives of 14-hydroxy-21-nor-5β,14β-pregnane and 5β,14β-pregnane C-3 α-L-rhamnosides and tris-β-D-digitoxosides is described. These derivatives, possessing a C-17β COCH2OH, CH2OH, CO2H, CO2Me, CH2NH2, or CH2NO2 group, bind to the digitalis receptor recognition site of heart muscle as measured in a radioligand binding assay. The 21-norpregnane derivatives consistently show greater binding affinity than the corresponding 20α- and 20β-pregnane analogs. The C-20 nitro rhamnoside is comparable to digitoxin in binding affinity. The 17β-CH2NO2 group is the most effective replacement for the unsaturated lactone in the binding assay found so far, showing binding affinity comparable to that of the cardiac glycosides.