1453813-96-1

Basic information

• Product Name: tert-butyl (4-(3-hydroxy-3-methylbut-1-yn-1-yl)phenyl)carbamate
• Synonyms: tert-butyl (4-(3-hydroxy-3-methylbut-1-yn-1-yl)phenyl)carbamate
• CAS NO: 1453813-96-1
• Molecular Weight: 275.348
• Mol File: 1453813-96-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl (4-(3-hydroxy-3-methylbut-1-yn-1-yl)phenyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (4-(3-hydroxy-3-methylbut-1-yn-1-yl)phenyl)carbamate(1453813-96-1)
• EPA Substance Registry System: tert-butyl (4-(3-hydroxy-3-methylbut-1-yn-1-yl)phenyl)carbamate(1453813-96-1)

Safety Data

• Hazardous Substances Data: 1453813-96-1(Hazardous Substances Data)

Upstream product

• 1453814-00-0 tert-butyl (4-(3-methyl-3-((2-nitrobenzyl)oxy)but-1-yn-1-yl)phenyl)carbamate 
• 115-19-5 2-methyl-but-3-yn-2-ol 
• 131818-17-2 tert-butyl (4-bromophenyl)carbamate 

Downstream Products

• 82815-75-6 <4-(4-aminophenyl)>-2-methyl-3-butyn-2-ol 
• 1453814-00-0 tert-butyl (4-(3-methyl-3-((2-nitrobenzyl)oxy)but-1-yn-1-yl)phenyl)carbamate 

Relevant articles and documents

A photolabile protection strategy for terminal alkynes

We present a strategy for photolabile protection of terminal alkynes. Several photo-caged alcohols were synthesized via mild copper(II)-catalyzed substitution between tertiary propargylic alcohols and 2-nitrobenzyl alcohol to build up robust, base stable o-nitrobenzyl (NB) photo-cleavable compounds. We compare the new photolabile protecting group with the commonly used alkyne protecting group, 2-methyl-3-butyn-2-ol and the results show that NB ethers are stable under the cleaving conditions for the cleavage of methylbutynol protected alkynes. Additionally, we present the synthesis of photo-cleavable NB derivatives containing thiol groups that can serve as agents for photoinduced surface functionalization reactions.