145459-53-6

Basic information

• Product Name: [1-(1,3-Dioxo-1,3-dihydro-isoindol-2-yloxy)-3-phenyl-propyl]-phosphonic acid diethyl ester
• Synonyms: [1-(1,3-Dioxo-1,3-dihydro-isoindol-2-yloxy)-3-phenyl-propyl]-phosphonic acid diethyl ester
• CAS NO: 145459-53-6
• Molecular Weight: 417.398
• Mol File: 145459-53-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [1-(1,3-Dioxo-1,3-dihydro-isoindol-2-yloxy)-3-phenyl-propyl]-phosphonic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [1-(1,3-Dioxo-1,3-dihydro-isoindol-2-yloxy)-3-phenyl-propyl]-phosphonic acid diethyl ester(145459-53-6)
• EPA Substance Registry System: [1-(1,3-Dioxo-1,3-dihydro-isoindol-2-yloxy)-3-phenyl-propyl]-phosphonic acid diethyl ester(145459-53-6)

Safety Data

• Hazardous Substances Data: 145459-53-6(Hazardous Substances Data)

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 524-38-9 N-hydroxyphthalimide 
• 81364-33-2 diethyl (1-hydroxy-3-phenylpropyl)phosphonate 

Downstream Products

• 124810-54-4 1-aminooxy-3-phenylpropylphosphonic acid 
• 145459-58-1 (1-Aminooxy-3-phenyl-propyl)-phosphonic acid diethyl ester 

Relevant articles and documents

ORGANIC PHOSPHORUS COMPOUNDS 102. AMINOOXYALKYLPHOSPHONIC ACIDS AND DERIVATIVES

Condensation of α-hydroxyalkylphosphonates, 1, with N-hydroxy-phthalimide using Mitsunobu's condition yields 1-phthalimido-N-oxyalkylphosphonates, 2, which on treatment with hydrazine give 1-aminooxyalkylphosphonates, 3.Hydrolysis of these with HCl produces 1-aminooxyalkylphosphonic acids, 4, in good yields.The reactions of 3 with dinitrodiphenyl ether, isocyanides, aldehydes and ketones are also reported. 1-Aminooxy-2-phenylethylphosphonic acid, 4g, is only a weak inhibitor of PAL, but 4i is a good inhibitor of anthocyanin synthesis.4g exhibits weak antifungal activity (against Botrytis cinerea) and 5a and 5b show herbicidal activity against dicotyledonous weeds. Key words: 1-Aminooxyalkylphosphonates; 1-aminooxyalkylphosphonic acids; physical properties; NMR-spectra; biological activity.