1454649-80-9

Basic information

• Product Name: 4-(2-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-4-(4-chlorophenyl)thiazol-5-yl)benzenesulfonamide
• Synonyms: 4-(2-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-4-(4-chlorophenyl)thiazol-5-yl)benzenesulfonamide
• CAS NO: 1454649-80-9
• Molecular Weight: 490.003
• Mol File: 1454649-80-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-4-(4-chlorophenyl)thiazol-5-yl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-4-(4-chlorophenyl)thiazol-5-yl)benzenesulfonamide(1454649-80-9)
• EPA Substance Registry System: 4-(2-(3-oxa-8-azabicyclo[3.2.1]octane-8-carbonyl)-4-(4-chlorophenyl)thiazol-5-yl)benzenesulfonamide(1454649-80-9)

Safety Data

• Hazardous Substances Data: 1454649-80-9(Hazardous Substances Data)

Upstream product

• 1454650-25-9 3-oxa-8-azabicyclo[3.2.1]octan-8-yl(5-bromo-4-(4-chlorophenyl)thiazol-2-yl)methanone 
• 613660-87-0 4-sulfamoylphenylboronic acid 
• 1454650-24-8 3-oxa-8-azabicyclo[3.2.1]octan-8-yl(4-(4-chlorophenyl)thiazol-2-yl)methanone 
• 280-07-9 3-oxa-8-aza-bicyclo[3.2.1]octane 
• 1454650-23-7 3-oxa-8-azabicyclo[3.2.1]octan-8-yl(4-bromothiazol-2-yl)methanone 

Relevant articles and documents

THIAZOLE DERIVATIVES AS ALPHA 7 NACHR MODULATORS

Disclosed is a compound of formula (I) wherein Y, Ring D, m and R1-R4 are as described herein, as a modulator of nicotinic acetylcholine receptors particularly the α7 subtype, in a subject in need thereof, as well as pharmaceutically acceptable salts, polymorphs, solvates, and isomers thereofs, for use either alone or in combinations with suitable other medicaments, and pharmaceutical compositions containing such compounds. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like.