14547-72-9Relevant articles and documents
Copper-mediated ortho C–H primary amination of anilines
Cheng, Tai-Jin,Wang, Xing,Xu, Hui,Dai, Hui-Xiong
supporting information, (2021/05/10)
We report herein a copper-mediated ortho C–H primary amination of anilines by using cheap and commercially available benzophenone imine as the amination reagent. The protocol show good functional group tolerance and heterocyclic compatibility. Late-stage diversification of drugs demonstrate the synthetic utility of this protocol.
Copper(ii) mediatedorthoC-H alkoxylation of aromatic amines using organic peroxides: efficient synthesis of hindered ethers
Ghosh, Subhash Chandra,Sahoo, Tapan,Sarkar, Souvik,Sen, Chiranjit
supporting information, p. 8949 - 8952 (2021/09/10)
Synthesis of hindered alkyl aryl ether derivatives (R-O-Ar) remains a huge challenge and highly desirable in organic and medicinal chemistry because extensive substitution on the ether bond prevents the undesired metabolic process and thus avoids rapid de
Method for selectively synthesizing halogenated arylamine through copper catalysis (by machine translation)
-
Paragraph 0075-0078, (2020/12/30)
The method comprises the following steps: reacting a substrate with a halogenating reagent (III) in an organic solvent to obtain a catalyst. The reaction 0 - 80 °C is reacted at 0.5 - 6h under the action of an oxidizing agent, and after the reaction is finished, the reaction liquid is subjected to post-treatment to obtain the product halogenated aromatic amine compound. To the invention, direct synthesis of the halogenated aromatic amine compounds is achieved for the first time, and the problems that in the traditional method, the metal catalyst is expensive, the halogenated reagent toxicity is large, byproducts are large and the like are solved. At the same time, the product can take off the pyridine guide group through simple hydrolysis, and further functional groups can be combined into an aromatic heterocyclic compound. The method is simple and convenient to operate, mild in reaction conditions, high in selectivity, high in product yield and wide in substrate applicability, and is an efficient organic synthesis means. : Substrate: Halogenating agent: Product: (by machine translation)
