14548-50-6

Basic information

• Product Name: 7-CHLORO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE
• Synonyms: 7-CHLORO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE;7-Chloro-3,4-dihydroquinolin-2(1H)-one;2(1H)-Quinolinone,7-chloro-3,4-dihydro-;7-Chloro-3,4-dihydroquinolin-2(1H)
• CAS NO: 14548-50-6
• Molecular Formula: C₉H₈ClNO
• Molecular Weight: 181.61892
• Mol File: 14548-50-6.mol
• Article Data: 10

Chemical Properties

• Melting Point: 194-196 °C(Solv: ethanol (64-17-5))
• Boiling Point: 345 °C at 760 mmHg
• Flash Point: 162.5 °C
• Appearance: /
• Density: 1.29 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.08±0.20(Predicted)
• CAS DataBase Reference: 7-CHLORO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-CHLORO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE(14548-50-6)
• EPA Substance Registry System: 7-CHLORO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE(14548-50-6)

Safety Data

• Hazardous Substances Data: 14548-50-6(Hazardous Substances Data)

Usage

General Description

7-Chloro-3,4-dihydro-1H-quinolin-2-one is a chemical compound that falls under the category of quinolines, which essentially are heterocyclic aromatic organic compounds. It is not widely studied, so information about its properties and uses is somewhat limited. However, due to its structure, it can be inferred that it may be used or utilized in research surrounding pharmaceuticals or functional materials, as other quinolines have been known to possess biological and pharmacological activity. Detail information regarding its potential characteristics such as toxicity, reactivity, physical properties, and environmental impact is not readily available.

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Downstream Products

• 131637-35-9 7-Chloro-1-{3-[4-(2-chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-2-yl]-prop-2-ynyl}-3,4-dihydro-1H-quinolin-2-one 
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Relevant articles and documents

Visible-Light Induced C(sp2)?H Amidation with an Aryl–Alkyl σ-Bond Relocation via Redox-Neutral Radical–Polar Crossover

We report an approach for the intramolecular C(sp2)?H amidation of N-acyloxyamides under photoredox conditions to produce δ-benzolactams with an aryl-alkyl σ-bond relocation. Computational studies on the designed reductive single electron transfer strategy led us to identify N-[3,5-bis(trifluoromethyl)benzoyl] group as the most effective amidyl radical precursor. Upon the formation of an azaspirocyclic radical intermediate by the selective ipso-addition with outcompeting an ortho-attack, radical–polar crossover was then rationalized to lead to the rearomative ring-expansion with preferential C?C bond migration.

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Provided herein are novel heterocyclic compounds, for example, compounds having Formula I, I-P, II, lI-P, or III. Also provided herein are pharmaceutical compositions comprising the compounds and methods of using the same, for example, in inhibiting aldehyde dehydrogenases and/or for treating various cancers, cancer metastasis, type 2 diabetes, pulmonary arterial hypertension (PAH) or neointimal hyperplasia (NIH).

The synthesis of N-heterocycles via copper/TEMPO catalysed aerobic oxidation of amino alcohols

N-Heterocycles can be prepared using alcohol oxidation as a key synthetic step. Herein we report studies exploring the potential of Cu/TEMPO as an aerobic oxidation catalyst for the synthesis of substituted indoles and quinolines.