1455483-41-6

Basic information

• Product Name: 4-(bromomethyl)-N-(2-(tert-butyldimethylsilyloxy)phenyl)benzenesulfonamide
• Synonyms: 4-(bromomethyl)-N-(2-(tert-butyldimethylsilyloxy)phenyl)benzenesulfonamide
• CAS NO: 1455483-41-6
• Molecular Weight: 456.476
• Mol File: 1455483-41-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(bromomethyl)-N-(2-(tert-butyldimethylsilyloxy)phenyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(bromomethyl)-N-(2-(tert-butyldimethylsilyloxy)phenyl)benzenesulfonamide(1455483-41-6)
• EPA Substance Registry System: 4-(bromomethyl)-N-(2-(tert-butyldimethylsilyloxy)phenyl)benzenesulfonamide(1455483-41-6)

Safety Data

• Hazardous Substances Data: 1455483-41-6(Hazardous Substances Data)

Upstream product

• 66176-39-4 4-(bromomethyl)benzene-1-sulfonyl chloride 
• 69589-21-5 O-tert-butyldimethylsilyl-2-aminophenol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1455483-48-3 4-(N-(2-hydroxyphenyl)sulfamoyl)benzyl phenylcarbamate 
• 1455483-49-4 O-4-(N-(2-hydroxyphenyl)sulfamoyl)benzyl phenylcarbamothioate 
• 1455483-50-7 4-(N-(2-((2-methoxyethoxy)methoxy)phenyl)-N-((2-methoxyethoxy)methyl)sulfamoyl)benzyl benzylcarbamate 
• 1455483-51-8 O-4-(N-(2-((2-methoxyethoxy)methoxy)phenyl)-N-((2-methoxyethoxy)methyl)sulfamoyl)benzyl benzylcarbamothioate 
• 1455483-52-9 4-(N-(2-hydroxyphenyl)sulfamoyl)benzyl benzylcarbamate 
• 1455483-53-0 O-4-(N-(2-hydroxyphenyl)sulfamoyl)benzyl benzylcarbamothioate 
• 1455483-54-1 4-(N-(2-((2-methoxyethoxy)methoxy)phenyl)-N-((2-methoxyethoxy)methyl)sulfamoyl)benzyl naphthalen-1-ylcarbamate 
• 1455483-55-2 4-(N-(2-hydroxyphenyl)sulfamoyl)benzyl naphthalen-1-ylcarbamate 
• 1455483-42-7 4-(bromomethyl)-N-(2-hydroxyphenyl)benzenesulfonamide 
• 1455483-43-8 4-(N-(2-hydroxyphenyl)sulfamoyl)benzyl acetate 
• 1455483-44-9 4-(N-(2-((2-methoxyethoxy)methoxy)phenyl)-N-((2-methoxyethoxy) methyl)sulfamoyl)benzyl acetate 
• 1455483-45-0 4-(hydroxymethyl)-N-(2-((2-methoxyethoxy)methoxy)phenyl)-N-((2-methoxyethoxy)methyl)benzenesulfonamide 
• 1455483-46-1 4-(N-(2-((2-methoxyethoxy)methoxy)phenyl)-N-((2-methoxyethoxy)methyl)sulfamoyl)benzyl phenylcarbamate 
• 1455483-47-2 O-4-(N-(2-((2-methoxyethoxy)methoxy)phenyl)-N-((2-methoxyethoxy)methyl)sulfamoyl)benzyl phenylcarbamothioate 

Relevant articles and documents

Synthesis of novel N-(2-Hydroxyphenyl)arylsulfonamides as selective HDAC inhibitory and cytotoxic agents

Based on the finding that the 2-aminobenzamido group of MS-275 plays a crucial role in inhibiting HDACs through chelation of zinc existing at the active site of HDAC enzymes, novel N-(2-hydroxyphenyl)aryl-sulfonamide derivatives were synthesized for their potential ability to inhibit HDACs and evaluated for anticancer activity against human breast cancer cell line (MCF-7). Although the synthesized arylsulfonamides have failed to significantly inhibit total HDACs activity, phenyl carbamate-linked arylsulfonamide 10 and benzyl thiocarbamate-linked arylsulfonamide 15 exhibited good anticancer activities, which were only 4.3- and 3.6-fold lower anticancer activities, respectively, than MS-275 that is undergoing phase II clinical trials. These results suggest that these compounds may act as a selective HDAC inhibitor and probably N-(2-hydroxy-phenyl)sulfamoyl group may play an important role in interacting with HDAC enzymes through chelation of zinc ion.