145614-17-1

Basic information

• Product Name: (-)-(R)-N-isopropylidene-α-aminophenylacetamide
• CAS NO: 145614-17-1
• Molecular Weight: 190.245
• Mol File: 145614-17-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (-)-(R)-N-isopropylidene-α-aminophenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-(R)-N-isopropylidene-α-aminophenylacetamide(145614-17-1)
• EPA Substance Registry System: (-)-(R)-N-isopropylidene-α-aminophenylacetamide(145614-17-1)

Safety Data

• Hazardous Substances Data: 145614-17-1(Hazardous Substances Data)

Upstream product

• 700-63-0 (R)-phenylglycine amide 
• 67-64-1 acetone 
• 19883-41-1 D-phenylglycine methyl ester hydrochloride 
• 875-74-1 (R)-phenylglycine 

Relevant articles and documents

Influence of a Hydroalcoholic Solvent on the Enantioselectivity of α-Amino nitrile Hydration Catalysed by Chiral Ketones

The enantioselective hydration of α-aminonitriles 1, RCH(CN)NH2 i; 1c: R = Ph> has been achieved in an alkaline hydroalcoholic medium in the presence of chiral ketonic catalysts.Of the different ketones used, (-)-(5R,3R,2R)-5-(methylethenyl)-3-cyano-2-methylcyclohexanone (8) gives rise to significant enantioselectivity D/kL = 2.1; T = 10 deg C; solvent, water-propan-2-ol (45:55,v/v)>.Although the structure of the catalyst could probably be improved, we show in this paper that the efficiency and especiallythe enantioselectivity of the catalyst are not only under steric control but also depend on the nature and composition of the hydroalcoholic solvent.Thus, for the three aminonitriles studied in the presence of the catalyst 8, the increase in percentage of propan-2-ol favours the hydration of the D α-aminonitrile as shown for the hydration of 1c for which the ratio kD/kL increases threefold when the percentage of propan-2-ol increases from 10 to 95percent.