1456809-28-1Relevant articles and documents
Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors
Myung, Nojoon,Connelly, Stephen,Kim, Boyoung,Park, Sung Jean,Wilson, Ian A.,Kelly, Jeffery W.,Choi, Sungwook
, p. 9188 - 9190 (2013/09/24)
We describe coumarin derivatives that are non-fluorescent in aqueous buffers and that very selectively bind to transthyretin (TTR) in complex biological environments potently inhibiting TTR amyloidogenesis while also exhibiting sensitive off-on fluorescen