1456900-24-5

Basic information

• Product Name: 6-chloro-2-(4-methylphenyl)-4-(trifluoromethyl)quinoline
• Synonyms: 6-chloro-2-(4-methylphenyl)-4-(trifluoromethyl)quinoline
• CAS NO: 1456900-24-5
• Molecular Weight: 321.729
• Mol File: 1456900-24-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-chloro-2-(4-methylphenyl)-4-(trifluoromethyl)quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2-(4-methylphenyl)-4-(trifluoromethyl)quinoline(1456900-24-5)
• EPA Substance Registry System: 6-chloro-2-(4-methylphenyl)-4-(trifluoromethyl)quinoline(1456900-24-5)

Safety Data

• Hazardous Substances Data: 1456900-24-5(Hazardous Substances Data)

Upstream product

• 154598-53-5 1-(2-amino-5-chloro-phenyl)-2,2,2-trifluoro-ethanone 
• 766-97-2 4-n-methylphenylacetylene 
• 173676-59-0 1-(2-amino-5-chlorophenyl)-2,2,2-trifluoroethanone hydrochloride 

Relevant articles and documents

NHC-Cu(I)-Catalyzed Friedl?nder-Type Annulation of Fluorinated o-Aminophenones with Alkynes on Water: Competitive Base-Catalyzed Dibenzo[b,f][1,5]diazocine Formation

An efficient, easily scalable synthesis of 4-trifluoromethylquinolines and naphthydrines (as well as their difluoro- and perfluoro-analogues) as a result of tandem direct catalytic alkynylation/dehydrative condensation of o-aminofluoromethylketones (o-FMKs), for the first time catalyzed by NHC-copper(I) complexes on water, is reported. A wide range of terminal alkynes is tolerated under the reaction conditions, including β-lactam-, steroid-, and sugar-derived ones, leading to desired quinolines and naphthydrines with good yields. Further investigations proved that o-FMKs could be efficiently transformed into a rare class of heterocyclic compounds - dibenzo[b,f][1,5]diazocines - by a base-catalyzed condensation, also on water. The developed method was applied for gram-scale synthesis of a fluorinated analogue of G protein-coupled receptor antagonist (GPR91).