14571-47-2

Basic information

• Product Name: 1,4-Cyclohexanedicarbonyl dichloride, cis- (9CI)
• Synonyms: 1,4-Cyclohexanedicarbonyl dichloride, cis- (9CI)
• CAS NO: 14571-47-2
• Molecular Formula: C₈H₁₀Cl₂O₂
• Molecular Weight: 209.0698
• Product Categories: ACIDHALIDE
• Mol File: 14571-47-2.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 258.9±33.0 °C(Predicted)
• Appearance: /
• Density: 1.317±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1,4-Cyclohexanedicarbonyl dichloride, cis- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Cyclohexanedicarbonyl dichloride, cis- (9CI)(14571-47-2)
• EPA Substance Registry System: 1,4-Cyclohexanedicarbonyl dichloride, cis- (9CI)(14571-47-2)

Safety Data

• Hazardous Substances Data: 14571-47-2(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Strong, pungent

Uses

a. Production of polymeric materials
b. Intermediate in manufacturing of pharmaceuticals and agrochemicals
c. Synthesis of various organic compounds
d. Crosslinking agent in polymeric materials production

Hazards

a. Harmful if inhaled, swallowed, or comes into contact with the skin
b. Causes irritation to the respiratory system and skin

Safety precautions

a. Handle with caution
b. Use in a well-ventilated area
c. Store away from incompatible materials and sources of ignition

Upstream product

• 619-81-8 cyclohexane-1,4-dicarboxylic acid 
• 94-60-0 dimethyl 1,4-cyclohexane dicarboxylate 
• 619-81-8 cis-cyclohexane-1,4-dicarboxylic acid 
• 13170-66-6 trans-1,4-cyclohexanedicarboxylic acid dichloride 
• 619-82-9 trans-hexahydroterephthalic acid 

Downstream Products

• 4322-09-2 1,4-dicarbonyl-cyclohexane 
• 70925-16-5 cis-cyclohexane-dicarboxylic acid-(1.4)-diamide 
• 13170-66-6 trans-1,4-cyclohexanedicarboxylic acid dichloride 
• 54657-09-9 trans-1,4-di(carboxamido)cyclohexane 
• 16813-46-0 N,N'-Bis-(2-chloroethyl)-trans-1,4-cyclohexandicarboxamid 
• 14818-30-5 trans-1,4-Bis-<1-oxo-3-methyl-4-methoxycarbonyl-buten-(3)-yl>-cyclohexan 
• 7006-80-6 N,N'-Di(2-chlorobenzyl)cyclohexane-trans-1,4-bis(carboxamide) 
• 94-60-0 dimethyl 1,4-cyclohexane dicarboxylate 
• 72213-11-7 trans-1,4-(4'-n-Propoxyphenyl)cyclohexandicarboxylat 

Relevant articles and documents

Method for preparing 1, 4-diphenyl cyclohexanedicarboxylate

The invention belongs to the field of chemical synthesis and specifically relates to a method for preparing 1, 4-diphenyl cyclohexanedicarboxylate. The method comprises the following steps: performinga reaction in a solvent under the action of a catalyst

POLYMERIZABLE COMPOUND AND OPTICALLY ANISOTROPIC BODY

PROBLEM TO BE SOLVED: To provide a polymerizable compound which has high storage stability and can form a film-like polymer while being difficult to cause alignment defects, where the film-like polymer is less likely to be separated from a substrate even when irradiated with ultraviolet for a long time. SOLUTION: The invention provides a compound represented by general formula (I), and a polymer thereof. A composition comprising the compound is useful as a polymerizable liquid crystal composition. (For example, the compound is bis[4-(acryloyloxyethoxy-ethoxy-ethoxy)phenyl]1,4-cyclohexanedicarboxylate.) SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

Novel bivalent securinine mimetics as topoisomerase I inhibitors

A series of novel bivalent securinine mimetics incorporating different linkers between C-15 and C-15′ were synthesized and their topoisomerase I (Topo I) inhibitory activities evaluated. It was thus revealed that mimetic R2 incorporating a rigid m-substituted benzene linker exhibits Topo I inhibitory activity three times that of parent securinine. Comprehensive structure-activity relationship analyses in combination with docking studies were used to rationalize the potent activity of these bivalent mimetics. Mechanistic studies served to confirm the deductions arising from docking studies that the active bivalent mimetics not only inhibited complexation between Topo I and DNA but also stabilized the Topo I-DNA complex itself.