145781-92-6 Usage
Description
Goserelin acetate is a synthetic decapaptide and a potent analog of LHRH (luteinizing hormone-releasing hormone). It is a synthetic superagonist nonapeptide analogue of GnRH that possesses greater potency than the natural hormone. Goserelin acetate is used in the form of a small, solid pellet that is administered as a subcutaneous implant for the palliative treatment of advanced, metastatic breast cancer in preand perimenopausal women or as a palliative in advanced prostatic cancer. It is also approved for use in treating endometriosis for up to 6 months.
Uses
1. Used in Anticancer Applications:
Goserelin acetate is used as an injectable gonadotropin-releasing hormone superagonist (GnRH agonist) for its luteinizing hormone antiproliferative activity in breast, prostate, and endometrial cancers. As a superagonist, it brings the levels of estradiol or testosterone to near castrate levels, thus slowing the progression of breast or prostate carcinoma, respectively.
2. Used in Hormone-Dependent Cancer Treatment:
Goserelin acetate is used as an antineoplastic (hormonal) agent in the treatment of hormone-dependent breast and prostate cancers. It binds to the GnRH receptor and increases intracellular calcium in αT3-1 cells, inducing testosterone production in vitro. It also inhibits tumor growth in a DU145 human prostate carcinoma mouse xenograft model when administered at a dose of 100 μg per day.
3. Used in Endometriosis Treatment:
Goserelin acetate is used as a treatment for endometriosis for up to 6 months. It helps in managing the symptoms and reducing the size of endometrial tissue growths.
4. Used in Uterine Fibroids Treatment:
Goserelin acetate is also used in the treatment of uterine fibroids, where it helps in reducing the size of the fibroids and alleviating the symptoms associated with them.
Chemical Properties:
Goserelin acetate is a white solid.
Biochem/physiol Actions
Goserelin acetate peptide results in significant inhibition of gonadotropin release and suppresses steroidogenesis in ovaries and testis. Thus, it leads to a reduction of testosterone to castration levels and estrogen to postmenopausal levels. Therefore, this peptide is used for reducing testosterone levels in patients with locally advanced prostate cancer.
Clinical Use
Goserelin acetate also is used in combination with the antiandrogen flutamide for shrinking
prostate carcinoma before radiation therapy. This maximal androgen blockade combination is
used when the prostate carcinoma has been staged as locally confined to the prostate gland,
with one or both lobes as well as the seminal vesicles involved. The treatment should start 8
weeks before radiation treatment begins and be continued throughout the radiation therapy.
Furthermore, women who are to undergo hysterectomy for menorrhagia can benefit from
previous treatment with goserelin acetate, because it is able to induce endometrial thinning.
This thinning of the endometrium improves the operating environment by causing less
intrauterine bleeding, increased postoperative amenorrhea, and decreased dysmenorrhea
following surgery, which is why goserelin acetate is approved for inducing endometrial thinning
prior to a patient undergoing a hysterectomy for heavy menstrual bleeding.
Check Digit Verification of cas no
The CAS Registry Mumber 145781-92-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,7,8 and 1 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 145781-92:
(8*1)+(7*4)+(6*5)+(5*7)+(4*8)+(3*1)+(2*9)+(1*2)=156
156 % 10 = 6
So 145781-92-6 is a valid CAS Registry Number.
InChI:InChI=1/C59H84N18O14.C2H4O2/c1-31(2)22-40(49(82)68-39(12-8-20-64-57(60)61)56(89)77-21-9-13-46(77)55(88)75-76-58(62)90)69-54(87)45(29-91-59(3,4)5)74-50(83)41(23-32-14-16-35(79)17-15-32)70-53(86)44(28-78)73-51(84)42(24-33-26-65-37-11-7-6-10-36(33)37)71-52(85)43(25-34-27-63-30-66-34)72-48(81)38-18-19-47(80)67-38;1-2(3)4/h6-7,10-11,14-17,26-27,30-31,38-46,65,78-79H,8-9,12-13,18-25,28-29H2,1-5H3,(H,63,66)(H,67,80)(H,68,82)(H,69,87)(H,70,86)(H,71,85)(H,72,81)(H,73,84)(H,74,83)(H,75,88)(H4,60,61,64)(H3,62,76,90);1H3,(H,3,4)/t38-,39-,40-,41-,42-,43-,44-,45+,46-;/m0./s1