145854-59-7

Basic information

• Product Name: MAS 7
• Synonyms: ILE-ASN-LEU-LYS-ALA-LEU-ALA-ALA-LEU-ALA-LYS-ALA-LEU-LEU-NH2;H-ILE-ASN-LEU-LYS-ALA-LEU-ALA-ALA-LEU-ALA-LYS-ALA-LEU-LEU-NH2;INLKALAALAKALL-NH2;MASTOPARAN 7;MAS 7;MASTOPARAN 7 SYNTHETIC >98%;mastoparan from polistes jadwagae;19: PN: WO2010069074 SEQID: 17 claimed protein
• CAS NO: 145854-59-7
• Molecular Formula: C77H127N21O18
• Molecular Weight: 1634.98
• Product Categories: Peptide;Phospholipase Activators;Lipids in Cell Signaling;Phospholipid Metabolism;G-Protein
• Mol File: 145854-59-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 1649.9°Cat760mmHg
• Flash Point: 951.6°C
• Appearance: /lyophilized powder
• Density: 1.154g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: −20°C
• PKA: 13.43±0.46(Predicted)
• CAS DataBase Reference: MAS 7(CAS DataBase Reference)
• NIST Chemistry Reference: MAS 7(145854-59-7)
• EPA Substance Registry System: MAS 7(145854-59-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 145854-59-7(Hazardous Substances Data)

Usage

Description

MAS 7, also known as Mastoparan-7, is an analog of the mastoparan peptide derived from the venom of Vespula lewisii, a species of wasp. It is a bioactive peptide with unique properties that have attracted significant interest in various research and application areas.

Uses

Used in Pharmaceutical Research:
MAS 7 is used as a research tool for studying mastoparan-stimulated nucleotide binding to G proteins. This application is crucial in understanding the interactions between G proteins and their ligands, which play a vital role in signal transduction pathways in cells.
Used in Biochemical Studies:
In the field of biochemistry, MAS 7 is employed to investigate the structural and functional aspects of G proteins and their interactions with other cellular components. This helps in elucidating the mechanisms underlying various cellular processes and potential therapeutic targets.
Used in Drug Development:
Due to its ability to interact with G proteins, MAS 7 has potential applications in the development of drugs targeting G protein-coupled receptors (GPCRs), which are involved in a wide range of physiological functions and are important drug targets for various diseases.
Used in Venom Research:
MAS 7 is also used in the study of venom components and their biological activities. Understanding the properties and mechanisms of action of venom-derived peptides like MAS 7 can provide insights into the development of novel therapeutic agents and the treatment of conditions caused by venomous stings or bites.

Biochem/physiol Actions

Mastoparan-7 (Mas-7) stimulates the G protein subunit Gαo/i by its mode of action (to bind to the plasma membrane). It possesses antiviral activity and is associated with histamine release from mast cells. It is also involved in the induction of potent mitochondrial permeability and tumor cell cytotoxicity.

InChI:InChI=1/C67H124N18O15/c1-18-38(12)53(71)67(100)85-51(32-52(70)86)66(99)84-50(31-37(10)11)64(97)79-45(24-20-22-26-69)61(94)75-42(16)58(91)82-47(28-34(4)5)62(95)76-39(13)55(88)73-40(14)57(90)81-48(29-35(6)7)63(96)77-41(15)56(89)78-44(23-19-21-25-68)60(93)74-43(17)59(92)83-49(30-36(8)9)65(98)80-46(54(72)87)27-33(2)3/h33-51,53H,18-32,68-69,71H2,1-17H3,(H2,70,86)(H2,72,87)(H,73,88)(H,74,93)(H,75,94)(H,76,95)(H,77,96)(H,78,89)(H,79,97)(H,80,98)(H,81,90)(H,82,91)(H,83,92)(H,84,99)(H,85,100)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,53-/m0/s1