1459-48-9 Usage
Description
4-(1-ADAMANTYL)ANILINE, also known as 4-(1-adamantyl)phenylamine, is an organic compound with the molecular formula C15H21N. It is characterized by its adamantyl group, which is a rigid and symmetrical carbon cage structure, attached to an aniline moiety. This unique structure endows 4-(1-ADAMANTYL)ANILINE with specific chemical and physical properties, making it a versatile compound for various applications.
Uses
Used in Pharmaceutical Industry:
4-(1-ADAMANTYL)ANILINE is used as a reactant in the preparation of pyrroledione derivatives, which are inhibitors of glycogen synthase kinase-3 (GSK-3). These inhibitors play a crucial role in the development of novel therapeutic agents for the treatment of various diseases, including neurodegenerative disorders, diabetes, and cancer. The adamantyl group in 4-(1-ADAMANTYL)ANILINE provides structural rigidity and enhances the binding affinity of the resulting pyrroledione derivatives to GSK-3, thereby improving their inhibitory potency.
Check Digit Verification of cas no
The CAS Registry Mumber 1459-48-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,5 and 9 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1459-48:
(6*1)+(5*4)+(4*5)+(3*9)+(2*4)+(1*8)=89
89 % 10 = 9
So 1459-48-9 is a valid CAS Registry Number.
InChI:InChI=1/C16H21N/c17-15-3-1-14(2-4-15)16-8-11-5-12(9-16)7-13(6-11)10-16/h1-4,11-13H,5-10,17H2
1459-48-9Relevant articles and documents
Modes of Micromolar Host-Guest Binding of β-Cyclodextrin Complexes Revealed by NMR Spectroscopy in Salt Water
Tomecek, Josef,Cablova, Andrea,Hromadkova, Aneta,Novotny, Jan,Marek, Radek,Durnik, Ivo,Kulhanek, Petr,Pruckova, Zdenka,Rouchal, Michal,Dastychova, Lenka,Vicha, Robert
, p. 4483 - 4496 (2021)
Multitopic supramolecular guests with finely tuned affinities toward widely explored cucurbit[n]urils (CBs) and cyclodextrins (CDs) have been recently designed and tested as functional components of advanced supramolecular systems. We employed various spa
NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS
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Page/Page column 108, (2020/10/09)
The present disclosure compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the TEAD transcription factor, and are useful in the treatment of diseases related to the activity of TEAD transcription factor including, e.g., cancer and other diseases.
4-(1-Adamantyl)phenylalkylamines with potential antiproliferative activity
Koperniku, Ana,Foscolos, Angeliki-Sofia,Papanastasiou, Ioannis,Foscolos, George B.,Tsotinis, Andrew,Schols, Dominique
, p. 171 - 176 (2016/03/01)
Background: In our previous publications we have described the synthesis of aminosubstituded diaryl adamantanes and their pharmacological evaluation in vitro and in vivo against many cancer cell lines. More recently, we have reported the synthesis of mono