145908-29-8

Basic information

• Product Name: 2-BROMOMETHYL-4-CHLORO-BENZOIC ACID METHYL ESTER
• Synonyms: 2-BROMOMETHYL-4-CHLORO-BENZOIC ACID METHYL ESTER;Methyl 2-(broMoMethyl)-4-chlorobenzoate;Benzoic acid, 2-(broMoMethyl)-4-chloro-, Methyl ester
• CAS NO: 145908-29-8
• Molecular Formula: C₉H₈BrClO₂
• Molecular Weight: 263.52
• Mol File: 145908-29-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 319.5°C at 760 mmHg
• Flash Point: 147°C
• Appearance: /
• Density: 1.561g/cm³
• Vapor Pressure: 0.000337mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-BROMOMETHYL-4-CHLORO-BENZOIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMOMETHYL-4-CHLORO-BENZOIC ACID METHYL ESTER(145908-29-8)
• EPA Substance Registry System: 2-BROMOMETHYL-4-CHLORO-BENZOIC ACID METHYL ESTER(145908-29-8)

Safety Data

• RIDADR: 3261
• HazardClass: 8
• PackingGroup: Ⅱ
• Hazardous Substances Data: 145908-29-8(Hazardous Substances Data)

Usage

General Description

2-Bromomethyl-4-chloro-benzoic acid methyl ester is a chemical compound with the molecular formula C9H8BrClO2. It is a methyl ester derivative of 2-bromomethyl-4-chlorobenzoic acid, and is commonly used in chemical synthesis and pharmaceutical research. 2-BROMOMETHYL-4-CHLORO-BENZOIC ACID METHYL ESTER is a white to off-white crystalline solid with a melting point of 81-84°C. It is mainly utilized as an intermediate in the production of various pharmaceuticals and agrochemicals. Due to its potential for causing skin irritation and serious eye damage, proper handling and safety precautions are necessary when working with this compound.

InChI:InChI=1/C9H8BrClO2/c1-13-9(12)8-3-2-7(11)4-6(8)5-10/h2-4H,5H2,1H3

Upstream product

• 99585-12-3 4-chloro-2-methylbenzoic acid methyl ester 
• 7499-07-2 4-chloro-2-methylbenzoic acid 
• 67-56-1 methanol 

Downstream Products

• 515133-98-9 C₁₅H₁₃ClO₃ 
• 1022984-23-1 5-chloro-2-(4-dimethylaminophenyl)-2,3-dihydroisoindol-1-one 
• 1192348-24-5 methyl 2-[(3-carbamoyl-5-chloro-2-iminopyridin-1(2H)-yl)methyl]-4-chlorobenzoate hydrobromide 
• 1001336-16-8 methyl 4-chloro-2-formylbenzoate 

Relevant articles and documents

Br?nsted Acid Catalyzed Dearomatization by Intramolecular Hydroalkoxylation/Claisen Rearrangement: Diastereo- and Enantioselective Synthesis of Spirolactams

Described herein is a novel Br?nsted acid catalyzed intramolecular hydroalkoxylation/Claisen rearrangement, allowing the practical and atom-economic synthesis of a range of valuable spirolactams from readily available ynamides in generally good to excellent yields with excellent diastereoselectivities and broad substrate scope. Importantly, an unexpected dearomatization of nonactivated arenes and heteroaromatic compounds is involved in this tandem sequence. Moreover, an asymmetric version of this tandem cyclization was also achieved by efficient kinetic resolution by chiral phosphoric acid catalysis. In addition, the [3,3]-rearrangement is shown to be kinetically preferred over the related [1,3]-rearrangement by theoretical calculations.

PRMT5 INHIBITORS

The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts thereof, which are PRMT5 inhibitors.

AUTOTAXIN INHIBITORS COMPRISING A HETEROAROMATIC RING-BENZYL-AMIDE-CYCLE CORE

The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.