145913-74-2 Usage
Description
[(2R,5S)-5-(6-chloro-9H-purin-9-yl)-1,3-oxathiolan-2-yl]methanol, also known as abacavir, is a synthetic nucleoside analogue with potent antiviral properties. It is specifically designed to combat the replication of the HIV virus, making it a crucial component in the treatment of HIV infection and AIDS. Abacavir functions by inhibiting the reverse transcriptase enzyme, a vital element in the life cycle of the HIV virus, thereby reducing the viral load and slowing the progression of the disease.
Uses
Used in Pharmaceutical Industry:
Abacavir is used as an antiviral agent for the treatment of HIV infection and AIDS. It is effective in inhibiting the reverse transcriptase enzyme, which is essential for the replication of the HIV virus. By disrupting this process, abacavir helps to reduce the viral load in the body and slow down the progression of the disease.
Used in Combination Therapy for HIV:
Abacavir is often used in combination with other antiretroviral drugs as part of a comprehensive treatment regimen for HIV. This combination therapy approach enhances the overall effectiveness of the treatment and helps to prevent the development of drug-resistant strains of the virus.
Used in Various Formulations:
Abacavir is available in different formulations, including oral tablets and oral solution, making it accessible and convenient for patients to incorporate into their daily routines. This versatility in formulation options contributes to the drug's widespread use in the management of HIV infection and AIDS.
Used in Patient Monitoring:
Due to the potential for severe and life-threatening hypersensitivity reactions in some individuals, abacavir is used with careful patient monitoring by healthcare providers. This ensures that any signs of adverse reactions are promptly identified and addressed, maintaining patient safety and the effectiveness of the treatment regimen.
Check Digit Verification of cas no
The CAS Registry Mumber 145913-74-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,9,1 and 3 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 145913-74:
(8*1)+(7*4)+(6*5)+(5*9)+(4*1)+(3*3)+(2*7)+(1*4)=142
142 % 10 = 2
So 145913-74-2 is a valid CAS Registry Number.
145913-74-2Relevant articles and documents
Asymmetric Synthesis and Biological Evaluation of β-L-(2R,5S)- and α-L-(2R,5R)-1,3-Oxathiolane-Pyrimidine and -Purine Nucleosides as Potential Anti-HIV Agents
Jeong, Lak S.,Shinazi, Raymond F.,Beach, J. Warren,Kim, Hea O.,Nampalli, Satyanarayana,et al.
, p. 181 - 195 (2007/10/02)
In order to study the structure-acivity relationships of L-oxathiolanyl nucleosides as potential anti-HIV agents, a series of enantiomerically pure L-oxathiolanyl pyrimidine and purine nucleosides were synthesized and evaluated for anti-HIV-1 activity in human peripheral blood mononuclear (PBM) cells.The key intermediate 8 was synthesized starting from L-gulose via 1,6-thiaanhydro-L-gulopyranose.The acetate 8 was condensed with thymine, 5-substituted uracils and cytosines, 6-chloropurine, and 6-chloro-2-fluoropurine to give pyrimidine and purine nucleosides.Upon evaluation of these final nucleosides, the 5-fluorocytosine derivative 51 was found to be the most potent compound among those tested.In the case of 5-substituted cytosine analogues, the antiviral potency was found to be in the following decreasing order: cytosine (β-isomer) > 5-iodocytosine (β-isomer) > 5-fluorocytosine (α-isomer) > 5-methylcytosine (α-isomer) > 5-methylcytosine (β-isomer) > 5-bromocytosine (β-isomer) > 5-chlorocytosine (β-isomer).Among the thymine, uracil, and 5-substituted uracil derivatives, thymine (α-isomer) and uracil (β-isomer) derivatives exhibited moderate anti-HIV activity.In the purine series, the antiviral potency is found to be in the following decreasing order: adenine (β-isomer) > 6-chloropurine (β-isomer) > 6-chloropurine (α-isomer) > 2-NH2-6-Cl-purine (β-isomer) > guanine (β-isomer) > N6-methyladenine (α-isomer) > N6-methyladenine (β-isomer).The cytotoxicity was also determined in human PBM cells as well as Vero cells.None of the synthesized nucleosides was toxic up to 100 μ in PBM cells.
