145914-09-6Relevant articles and documents
Palladium-Catalyzed Fluoroarylation of gem-Difluoroenynes to Access Trisubstituted Trifluoromethyl Allenes
Qi, Shutao,Gao, Shiquan,Xie, Xiaoxiao,Yang, Junfeng,Zhang, Junliang
, p. 5229 - 5234 (2020)
Various new transformations of gem-difluoroalkenes leading to trifluoromethyl substituted compounds have been well established in the past years. However, the development of new transformations of gem-difluoroenynes lags much behind. Herein is reported the fluoroarylation of 1,1-difluoro-1,3-enynes with aryl halides in the presence of silver fluoride affording trisubstituted trifluoromethyl allenes under the catalysis of palladium. The reaction features mild conditions, high functional-group tolerance, and high regioselectivity.
Nickel-Catalyzed Allylmethylation of Alkynes with Allylic Alcohols and AlMe3: Facile Access to Skipped Dienes and Trienes
Li, Jincan,Li, Wanfang,Yu, Shun,Zhao, Yu
supporting information, p. 14404 - 14408 (2020/07/04)
We present herein an unprecedented allylative dicarbofunctionalization of alkynes with allylic alcohols. This simple catalytic procedure utilizes commercially available Ni(COD)2, triphenylphosphine, and inexpensive reagents, and delivers valuable skipped dienes and trienes with an all-carbon tetrasubstituted alkene unit in a highly stereoselective fashion. Preliminary mechanistic studies support the reaction pathway of allylnickelation followed by transmetalation in this dicarbofunctionalization of alkynes.
Cu-Catalyzed C-H Trifluoromethylation of 3-Arylprop-1-ynes for the Selective Construction of Allenic Csp2-CF3 and Propargyl Csp3-CF3 Bonds
Ji, Yun-Long,Luo, Jia-Jia,Lin, Jin-Hong,Xiao, Ji-Chang,Gu, Yu-Cheng
supporting information, p. 1000 - 1003 (2016/03/15)
A new method has been developed for the Cu-catalyzed C-H trifluoromethylation of 3-arylprop-1-ynes for the selective construction of allenic Csp2-CF3 and propargyl Csp3-CF3 bonds. The selective formation of alle
