1459161-09-1Relevant articles and documents
A novel asymmetric organocatalytic Michael-aldol-dehydration domino reaction for the construction of spirocyclic benzofuranones
Qi, Liang-Wen,Wang, Liang-Liang,Peng, Lin,Jia, Li-Na,Tian, Fang,Xu, Xiao-Ying,Wang, Li-Xin
, p. 9303 - 9308 (2013/10/01)
Organocatalytic Michael-aldol-dehydration domino reaction of 3-(1-hydroxyethylidene)benzofuran-2(3H)-ones and enones catalyzed by Cinchona-based primary amine has been developed. The desired chiral spirocyclic benzofuranones were obtained in excellent stereoselectivities (dr>20:1 and up to 96% ee) and moderate to excellent yields (up to 98%).