145934-81-2

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine, 5-chloro-2-methyl-
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine, 5-chloro-2-methyl-;5-Chloro-2-Methyl-7-azaindole;5-Chloro-2-Methyl-1H-pyrrolo[2,3-b]pyridine
• CAS NO: 145934-81-2
• Molecular Formula: C8H7ClN2
• Molecular Weight: 166.6076
• Mol File: 145934-81-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 300.8 °C at 760 mmHg
• Flash Point: 164.1 °C
• Appearance: /
• Density: 1.351 g/cm³
• Vapor Pressure: 0.00196mmHg at 25°C
• Refractive Index: 1.675
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine, 5-chloro-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine, 5-chloro-2-methyl-(145934-81-2)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine, 5-chloro-2-methyl-(145934-81-2)

Safety Data

• Hazardous Substances Data: 145934-81-2(Hazardous Substances Data)

Usage

General Description

1H-Pyrrolo[2,3-b]pyridine, 5-chloro-2-methyl- is a chemical compound with the molecular formula C8H6ClN. It is a chlorinated derivative of 1H-Pyrrolo[2,3-b]pyridine, a heterocyclic compound containing a pyridine and a pyrrole ring. The addition of a chlorine atom and a methyl group to the compound results in the 5-chloro-2-methyl- derivative. 1H-Pyrrolo[2,3-b]pyridine, 5-chloro-2-methyl- has potential applications in the field of pharmaceuticals and agrochemicals due to its unique structure and properties. Its potential uses may include as an intermediate in the synthesis of active pharmaceutical ingredients or in the development of new agrochemical products. Additionally, its chemical structure makes it of interest in the field of research and development of novel organic compounds.

InChI:InChI=1/C8H7ClN2/c1-5-2-6-3-7(9)4-10-8(6)11-5/h2-4H,1H3,(H,10,11)

Upstream product

• 1312755-53-5 5-chloro-3-prop-1-ynyl-pyridin-2-ylamine 
• 211308-81-5 5-chloro-3-iodo-2-aminopyridine 
• 1072-98-6 5-chloro-2-pyridylamine 

Downstream Products

• 954112-62-0 5-chloro-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 
• 936243-42-4 5-chloro-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-ylamine 

Relevant articles and documents

1, 7 - DIAZACARBAZOLES AND THEIR USE IN THE TREATMENT OF CANCER

The invention relates to 1, 7-diazacarbazole compounds of Formula (I), (I-a) and (I-b) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chk 1) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.