1459754-40-5 Usage
Description
(2-chloro-5-iodophenyl)(4-hydroxyphenyl)methanone is a chemical compound with the molecular formula C13H8ClIO2. It is known for its aromatic properties and is commonly used in organic chemistry research and pharmaceutical development. This highly reactive and potentially hazardous substance is often used as a building block for the synthesis of other organic compounds.
Uses
Used in Organic Chemistry Research:
(2-chloro-5-iodophenyl)(4-hydroxyphenyl)methanone is used as a research compound for studying organic chemistry reactions and mechanisms. Its unique structure and reactivity make it a valuable tool for understanding and developing new chemical processes.
Used in Pharmaceutical Development:
(2-chloro-5-iodophenyl)(4-hydroxyphenyl)methanone is used as a building block in the synthesis of pharmaceutical compounds. Its aromatic properties and reactivity contribute to the development of new drugs and therapeutic agents.
Used in Chemical Synthesis:
(2-chloro-5-iodophenyl)(4-hydroxyphenyl)methanone is used as a key intermediate in the synthesis of various organic compounds. Its versatility and reactivity make it an important component in the production of a wide range of chemical products.
It is important to handle and store (2-chloro-5-iodophenyl)(4-hydroxyphenyl)methanone with extreme caution, as it can be harmful if ingested, inhaled, or allowed to come into contact with the skin. Proper safety protocols and protective equipment should be used when working with this compound to minimize the risk of exposure and potential harm to individuals and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 1459754-40-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,5,9,7,5 and 4 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1459754-40:
(9*1)+(8*4)+(7*5)+(6*9)+(5*7)+(4*5)+(3*4)+(2*4)+(1*0)=205
205 % 10 = 5
So 1459754-40-5 is a valid CAS Registry Number.
1459754-40-5Relevant articles and documents
Design, synthesis and anticancer activities of halogenated Phenstatin analogs as microtubule destabilizing agent
Hu, Shengquan,Sun, Wuji,Wang, Yeming,Yan, Hong
, p. 465 - 472 (2019/02/09)
A series of halogenated Phenstatin analogs were designed as microtubule destabilizing agent by docking study. It was synthesized within three steps starting from 2-chloro-5-iodobenzoic acid and substituted benzene. All the products were characterized by 1H NMR and 13C NMR spectral analysis, and the stereochemical structure was also confirmed by a single crystal X-ray diffraction crystallographic analysis. The microtubule destabilizing activities were evaluated in vitro with human liver cancer Huh-7 cell line and human lung cancer A549 cell line. Some of the HPAs were achieved IC50 about 5.0 μM against human liver cancer Huh-7 cells. [Figure not available: see fulltext.].
Preparation method of Jardiance
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Paragraph 0045; 00046; 0047, (2017/07/21)
The invention discloses a preparation method of Jardiance. The preparation method comprises the following steps: (1) performing a Grignard exchange reaction on a compound 5, then enabling the compound 5 after the Grignard exchange reaction to react with a glucose lactone derivative 6 so as to obtain a compound 7 (as shown in the description), wherein X is bromine or iodine, LG is chlorine, bromine, mesyloxy or tosyl, and PG is acetyl, tert- butanoyl or benzoyl; (2) under the action of alkali, performing deprotection on the compound 7 so as to obtain a finished product namely an Jardiance type compound 8 (as shown in the description). The preparation route is simple to operate, the reaction steps are reduced, the yield is high, the obtained product is high in purity, and the preparation method is suitable for scaled production.
