146-21-4 Usage
Description
10-[3-(Dimethylamino)propyl]-10H-phenothiazine 5-oxide is a chemical compound derived from the phenothiazine class, which is known for its diverse range of applications in the pharmaceutical and chemical industries. This specific compound is characterized by its unique molecular structure, which includes a dimethylaminopropyl group attached to the phenothiazine core. This structure endows the compound with distinct properties and potential applications.
Uses
Used in Pharmaceutical Industry:
10-[3-(Dimethylamino)propyl]-10H-phenothiazine 5-oxide is used as an active pharmaceutical ingredient (API) for its antipsychotic properties. As a metabolite of Chlorpromazine and an impurity of Promazine, both of which are well-known antipsychotic drugs, this compound contributes to the overall therapeutic effects of these medications. It is particularly useful in the treatment of various psychiatric disorders, such as schizophrenia and bipolar disorder, by helping to manage symptoms like hallucinations, delusions, and mood swings.
Used in Chemical Research:
In the field of chemical research, 10-[3-(Dimethylamino)propyl]-10H-phenothiazine 5-oxide serves as a valuable compound for studying the structure-activity relationships of phenothiazine derivatives. Its unique molecular structure allows researchers to explore the effects of different functional groups on the compound's biological activity, potentially leading to the development of new and more effective antipsychotic drugs.
Used in Drug Synthesis:
10-[3-(Dimethylamino)propyl]-10H-phenothiazine 5-oxide can also be used as a key intermediate in the synthesis of other phenothiazine-based drugs. Its presence in the molecular structure can influence the pharmacological properties of the final product, making it a valuable building block for the development of novel therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 146-21-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 6 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 146-21:
(5*1)+(4*4)+(3*6)+(2*2)+(1*1)=44
44 % 10 = 4
So 146-21-4 is a valid CAS Registry Number.
146-21-4Relevant articles and documents
Preparation and electrochemical behavior of N-substituted phenothiazine oxide
Hayashi, Hideki,Koizumi, Take-Aki
, p. 1441 - 1449 (2016)
The chemical properties of promazine oxide (Prom-O) and promazine (Prom) were compared. Cyclic voltammetry (CV) experiments showed a higher oxidation potential of Prom-O compared to that of Prom. The results of CV measurements also suggested the potential applicability of Prom-O as an n-type semiconductor.
Formation of a promazine radical and promazine 5-oxide in the reaction of promazine with hydrogen peroxide: Mechanistic insight from kinetic and epr measurements
Wisniewska, Joanna,Wrzeszcz., Grzegorz,Koter, Stanislaw
, p. 1 - 9 (2010)
The kinetics of the oxidation of promazine (PMZ) by hydrogen peroxide was studied in the presence of a large excess of H2O2 in acidic chloride media using UV-vis spectroscopy. The reaction proceeds via two consecutive steps. In the first step, oxidation leads to formation of a promazine radical. In the second step, the promazine radical is oxidized to promazine 5- oxide. Electron paramagnetic resonance spectroscopy (EPR) results provide clear evidence for the formation of an intermediate promazine radical. Linear dependences of the pseudo-first- order rate constants (k1 and k2)on[H2O2] with a nonzero intercept were established for the first and the second process, respectively. The rate of the first stage of the reaction increased slightly with increasing concentration of O2, indicating the role of the OH? radicals on the redox process, which are transformed into the Cl2-? radicals. The mechanism of the overall reaction is discussed on the basis of all these kinetic measurements.
Copper(II)-catalyzed promazine oxidation by dioxygen in acidic aqueous solutions
Wisniewska,Kita
, p. 491 - 495 (2007/10/03)
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