146014-66-6

Basic information

• Product Name: Methyl2-Fluoro-6-iodobenzoate
• Synonyms: Methyl2-Fluoro-6-iodobenzoate;Benzoic acid, 2-fluoro-6-iodo-, methyl ester;2-Fluoro-6-iodo-benzoic acid methyl ester
• CAS NO: 146014-66-6
• Molecular Formula: C₈H₆FIO₂
• Molecular Weight: 280.0349132
• EINECS: -0
• Mol File: 146014-66-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 266.8±25.0 °C(Predicted)
• Appearance: /
• Density: 1.823±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl2-Fluoro-6-iodobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl2-Fluoro-6-iodobenzoate(146014-66-6)
• EPA Substance Registry System: Methyl2-Fluoro-6-iodobenzoate(146014-66-6)

Safety Data

• Hazardous Substances Data: 146014-66-6(Hazardous Substances Data)

Usage

Description

Methyl2-Fluoro-6-iodobenzoate is a chemical compound with the molecular formula C8H6FIO2. It is an organic compound that contains a methyl ester group (–COOCH3), a fluorine atom (F), and an iodine atom (I), attached to a benzene ring. This highly versatile compound has a wide range of potential applications in different fields of science and technology.

Uses

Used in Pharmaceutical Industry:
Methyl2-Fluoro-6-iodobenzoate is used as a building block for the synthesis of various drugs. Its unique structure, which includes a fluorine and iodine atom, allows for the development of new pharmaceutical compounds with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, Methyl2-Fluoro-6-iodobenzoate is used as a key component in the production of herbicides. Its chemical properties make it suitable for the creation of effective weed control agents.
Used in Organic Electronics:
Methyl2-Fluoro-6-iodobenzoate has been studied for its potential application in organic electronics. Its molecular structure lends itself to the development of new electronic materials and devices.
Used in Optoelectronic Devices:
Methyl2-Fluoro-6-iodobenzoate has also been explored for use in optoelectronic devices. Its properties make it a promising candidate for the creation of advanced optoelectronic technologies.

Upstream product

• 186581-53-3 diazomethane 
• 111771-08-5 2-fluoro-6-iodobenzoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 1121-86-4 1-Fluoro-3-iodobenzene 
• 851368-08-6 1-bromo-2-fluoro-6-iodobenzene 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 67-56-1 methanol 
• 111771-12-1 2-fluoro-6-iodobenzoyl chloride 

Downstream Products

• 152609-82-0 2-fluoro-6-(3-hydroxy-2-propyl-phenoxy)benzoic acid methyl ester 
• 272130-52-6 methyl 2-fluoro-6-(3-hydroxyprop-1-yn-1-yl)benzoate 
• 165803-49-6 2-(3-bromo-propyl)-6-fluoro-benzoic acid methyl ester 
• 1027730-33-1 2-fluoro-6-[3-(8-oxo-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-propyl]-benzoic acid methyl ester 
• 165801-62-7 2-fluoro-6-[3-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-propyl]-benzoic acid methyl ester 
• 1231747-23-1 C₁₅H₁₇FO₄ 
• 1293284-61-3 methyl 2-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 
• 1293284-62-4 methyl-2-fluoro-6-(pyrimidin-2-yl)benzoate 
• 1293284-60-2 2-fluoro-6-(pyrimidin-2-yl)benzoic acid 
• 1293912-40-9 (Z)-N'-((2-fluoro-6-iodobenzoyl)oxy)acetimidamide 
• 578729-12-1 5-(2-fluoro-6-iodophenyl)-3-methyl-1,2,4-oxadiazole 

Relevant articles and documents

Synthesis and antibacterial activity of racemic paecilocin A and its derivatives against methicillin-sensitive and -resistant Staphylococcus aureus

A total synthesis in four steps of racemic paecilocin A, a natural marine phthalide is reported. The synthetic pathway includes an iodine-magnesium exchange followed by a condensation on an aldehyde and represents a sufficiently flexible approach to allow the synthesis of twelve analogs. The synthesized compounds were investigated for their antibacterial activity against methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant strain (MRSA). Three analogs were found to have similar or better antibacterial activity than the natural compound on MRSA.

CHEMICAL COMPOUNDS

The invention relates to a novel compound of formula (I) or a stereoisomer, or a racemate or a mixture or a pharmaceutically acceptable salt thereof: wherein: R is phenyl or a 5- or 6-membered heteroaryl ring containing 1 to 3 heteroatoms selected from S, N and O, such rings may be optionally substituted with n groups Q; Q is selected from a group consisting of: C1-C4 alkyl, halogen, halo C1-C4 alkyl, C1-C4 alkoxy, CN, SO2CH3 or a group -O[(CR1R2]pQ1; or Q may be a group Q2; Q1 is phenyl, which may be optionally substituted with n substituents selected from a group consisting of: C1-C4 alkyl, halogen, halo C1-C4 alkyl, C1-C4 alkoxy, CN, or a group Q2; or corresponds to 2,2-difluoro- benzo[d][1,3]dioxol-4-yl; Q2 is a 5- or 6-membered heteroaryl containing at least one nitrogen atom, which may optionally substituted with n substituents selected from a group consisting of: C1 C1-C4 alkyl, halogen, halo C1-C4 alkyl, C1-C4 alkoxy, CN; P is a 6-membered heteroaryl or a 8-1 1 membered bicylic heteroaryl group, which may be substituted with n substituents selected from a group consisting of: C1-C4 alkyl, halogen, halo C1-C4 alkyl, C1-C4 alkoxy, CN; R1 is hydrogen or C1-C3 alkyl; R2 is hydrogen or C1-C3 alkyl; n is 1, 2 or 3; p is 0, 1 or 2; and with the proviso that when R corresponds to phenyl, P is substituted by at least one CF3; processes for the preparation of those compounds, pharmaceutical compositions containing one or more compounds of formula (I) and their use as dual antagonists of the Orexin 1 and Orexin 2 receptors.

FUSED HETEROCYCLIC COMPOUNDS AS OREXIN RECEPTOR MODULATORS

Disubstituted 3,8-diaza-bicyclo[4.2.0]octane and 3,6-diazabicyclo [3.2.0]heptane compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.