146063-29-8

Basic information

• Product Name: Bis(cbz-Val-Phe)phosphinate isostere
• Synonyms: 2,5,10,13-Tetraaza-7-phosphatetradecanedioic acid, 7-ethoxy-8-hydroxy-3,12-bis(1-methylethyl)-4,11-dioxo-6,9-bis(phenylmethyl)-, bis(phenylmethyl) ester, 7-oxide;Aids045050;Aids-045050;Bis(cbz-Val-Phe)phosphinate isostere
• CAS NO: 146063-29-8
• Molecular Formula: C₄₅H₅₇N₄O₉P
• Molecular Weight: 828.9292
• Mol File: 146063-29-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.209g/cm³
• Refractive Index: 1.571
• CAS DataBase Reference: Bis(cbz-Val-Phe)phosphinate isostere(CAS DataBase Reference)
• NIST Chemistry Reference: Bis(cbz-Val-Phe)phosphinate isostere(146063-29-8)
• EPA Substance Registry System: Bis(cbz-Val-Phe)phosphinate isostere(146063-29-8)

Safety Data

• Hazardous Substances Data: 146063-29-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C45H57N4O9P/c1-6-58-59(55,38(28-34-21-13-8-14-22-34)47-42(51)40(32(4)5)49-45(54)57-30-36-25-17-10-18-26-36)43(52)37(27-33-19-11-7-12-20-33)46-41(50)39(31(2)3)48-44(53)56-29-35-23-15-9-16-24-35/h7-26,31-32,37-40,43,52H,6,27-30H2,1-5H3,(H,46,50)(H,47,51)(H,48,53)(H,49,54)/t37?,38?,39-,40-,43?,59?/m0/s1

Upstream product

• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 146063-33-4 (2-Amino-1-hydroxy-3-phenyl-propyl)-((R)-1-amino-2-phenyl-ethyl)-phosphinic acid ethyl ester 
• 59830-60-3 benzyl (1S)-(1-formyl-2-phenylethyl)carbamate 
• 115961-51-8 Cbz-(R)-α-amino-phosphinic acid ethylester 
• 146063-28-7 (2-Benzyloxycarbonylamino-1-hydroxy-3-phenyl-propyl)-((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinic acid ethyl ester 

Downstream Products

• 146063-30-1 [2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-1-hydroxy-3-phenyl-propyl]-[1-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-2-phenyl-ethyl]-phosphinic acid 

Relevant articles and documents

New Hybrid Transition State Analog Inhibitors of HIV Protease with Peripheric C2-Symmetry

The synthesis of novel hybrid transition state analogs, a combination of phosphinic acid- and hydroxymethylene-type inhibitors of HIV protease, is demonstrated.These nonsymmetrical structures, placed in a peripheric C2-symmetrical environment,