1462-84-6

Basic information

• Product Name: 2,3,6-TRIMETHYLPYRIDINE
• Synonyms: 2,3,6-trimethyl-pyridin;Pyridine, 2,3,6-trimethyl-;2,3,6-COLLIDINE;2,3,6-TRIMETHYLPYRIDINE
• CAS NO: 1462-84-6
• Molecular Formula: C₈H₁₁N
• Molecular Weight: 121.18
• EINECS: 215-970-2
• Mol File: 1462-84-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: -56.98°C (estimate)
• Boiling Point: 180.91°C (estimate)
• Flash Point: 47.6°C
• Appearance: /
• Density: 0.9220
• Vapor Pressure: 1.43mmHg at 25°C
• Refractive Index: 1.5053
• PKA: pK1:7.60(+1) (25°C,)
• CAS DataBase Reference: 2,3,6-TRIMETHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,6-TRIMETHYLPYRIDINE(1462-84-6)
• EPA Substance Registry System: 2,3,6-TRIMETHYLPYRIDINE(1462-84-6)

Safety Data

• Hazardous Substances Data: 1462-84-6(Hazardous Substances Data)

Usage

Description

2,3,6-TRIMETHYLPYRIDINE is a colorless liquid with a density of 0.913 g/cm3. It is slightly soluble in water and can be found in low-temperature coal tar and coal soot.

Uses

Used in Chemical Synthesis:
2,3,6-TRIMETHYLPYRIDINE is used as a building block for the synthesis of various organic compounds due to its unique chemical structure and reactivity.
Used in Flavor and Fragrance Industry:
2,3,6-TRIMETHYLPYRIDINE is used as a flavoring agent for its characteristic aroma, adding a pleasant scent to various products.
Used in Pharmaceutical Industry:
2,3,6-TRIMETHYLPYRIDINE is used as an intermediate in the production of certain pharmaceutical compounds, contributing to the development of new drugs.
Used in Material Science:
2,3,6-TRIMETHYLPYRIDINE can be used as a component in the development of new materials, such as polymers and coatings, due to its chemical properties.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

2,3,6-TRIMETHYLPYRIDINE neutralizes acids in weakly exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides.

Fire Hazard

Flash point data for 2,3,6-TRIMETHYLPYRIDINE are not available, however, 2,3,6-TRIMETHYLPYRIDINE is probably combustible.

InChI:InChI=1/C8H11N/c1-6-4-5-7(2)9-8(6)3/h4-5H,1-3H3

Upstream product

• 741668-77-9 3-(chloromethyl)-2,6-dimethylpyridine 
• 50-00-0 formaldehyd 
• 78-93-3 butanone 
• 78-86-4 s-butyl chloride 
• 75-36-5 acetyl chloride 
• 75-05-8 acetonitrile 
• 74-99-7 prop-1-yne 
• 7664-41-7 ammonia 
• 67-64-1 acetone 
• 582303-10-4 (2,6-dimethylpyridin-3-yl)methanol 
• 1721-13-7 ethyl 2,6-dimethylnicotinate 
• 70271-80-6 ethyl 4-chloro-2,6-dimethylnicotinate 
• 38688-78-7 2,3,6-trimethyl-pyridine-1-oxide 
• 879133-16-1 4-chloro-2,3,6-trimethylpyridine N-oxide 

Relevant articles and documents

Inhibitors of cell proliferation, angiogenesis, fertility, and muscle contraction

The invention concerns inhibitors of cell proliferation, angiogenesis, fertility, and muscle contraction, characterized by formula I wherein, X, Y and Z independently represent C or N; ------ is an optional double bond; n is 0 or 1; R1, R2, and R4 independently represent hydrogen, a chemical bond, C1-10 alkyl; C2-10 alkenyl; C2-10 alkinyl; aryl; aryl-C1-10 alkyl; C3-10 heterocyclyl; C5-10 heteroaryl; halo, CF3; NO2; NHC(O)R*, OR, said alkyl, alkenyl, alkinyl, aryl, arylalkyl, heterocyclyl, or heteroaryl being optionally substituted; R3, R5, and R6 independently represent hydrogen, C1-10alkyl; C2-10 alkenyl; C2-10 alkinyl; aryl; aryl-C1-10alkyl; C3-10 heterocyclyl; C5-10 heteroaryl; halo, CF3; NO2; NHC(O)R*, OR, said alkyl, alkenyl, alkinyl, aryl, heterocyclyl, or heteroaryl being optionally substituted; or R5 and R6 together form a 5- or 6-member aryl, heterocyclyl or heteroaryl group; R is hydrogen or C1-6 alkyl; R* is hydrogen, or C1-6 alkyl, or OH, wherein the optional substituents are preferably selected from the group of one to three OH, C1-6 alkyl, halo, NO2, C1-6 alkoxy, and CF3, or a pharmaceutically acceptable salt thereof.

CATALYTIC SYNTHESIS OF PYRIDINE BASES BY CONDENSATION OF METHYL ETHYL KETONE WITH AMMONIA

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Improved Catalytic Activity of Cyclopentadienylcobalt in the Preparation of Pyridines from Acetylenes and Nitriles

The catalytic activity of cyclopentadienylcobalt increases greatly upon introducing a methoxycarbonyl group into the cyclopentadienyl ring, and by carrying out the reaction with a rigorous exclusion of oxygen.Among the precursors we have examined, the most active one was z)(cot)> (Cpz = methoxycarbonyl-substituted cyclopentadienyl; cot = cyclooctatetraene) which can generate the active species at 100 deg C.