1462-93-7

Basic information

• Product Name: 6-ethyl-2,3,4,5-tetrahydropyridine
• Synonyms: 2-Ethyl-3,4,5,6-tetrahydropyridine; Pyridine, 2-ethyl-3,4,5,6-tetrahydro-
• CAS NO: 1462-93-7
• Molecular Formula: C₇H₁₃N
• Molecular Weight: 111.1848
• Mol File: 1462-93-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 147.8°C at 760 mmHg
• Flash Point: 34.3°C
• Density: 0.92g/cm³
• Vapor Pressure: 5.52mmHg at 25°C
• Refractive Index: 1.496
• CAS DataBase Reference: 6-ethyl-2,3,4,5-tetrahydropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-ethyl-2,3,4,5-tetrahydropyridine(1462-93-7)
• EPA Substance Registry System: 6-ethyl-2,3,4,5-tetrahydropyridine(1462-93-7)

Safety Data

• Hazardous Substances Data: 1462-93-7(Hazardous Substances Data)

Usage

General Description

6-Ethyl-2,3,4,5-tetrahydropyridine is a chemical compound with the molecular formula C8H15N. It is a member of the tetrahydropyridine family, which are organic compounds containing a six-membered ring consisting of five carbon atoms and one nitrogen atom. The ethyl group in its name indicates the presence of a two-carbon chain attached to the nitrogen atom in the ring structure. 6-ethyl-2,3,4,5-tetrahydropyridine is commonly used in scientific research as a neurotoxin, specifically in the study of Parkinson's disease. It is known to induce symptoms similar to those of Parkinson's in animal models, making it a valuable tool for studying the pathophysiology and potential treatments for the disease. Additionally, it has also been used in the synthesis of other organic compounds due to its specific structural properties.

Upstream product

• 1462-92-6 6-methyl-2,3,4,5-tetrahydro-pyridine 
• 74-88-4 methyl iodide 
• 96333-47-0 2-Piperidin-(2Z)-ylidene-propionic acid ethyl ester 
• 107993-90-8 hepta-5,6-diene-1-amine 
• 85908-96-9 2-oxopiperidine-1-carboxylic acid tert-butyl ester 
• 1484-80-6 2-ethylpiperidine 
• 10297-06-0 1-chloro-5-hexyne 
• 70396-13-3 chloro-1 heptyne-5 
• 100-39-0 benzyl bromide 
• 161009-84-3 hepta-4,5-dienylamine 

Downstream Products

• 108201-24-7 2-Ethoxy-9a-ethyl-3,4-diphenyl-7,8,9,9a-tetrahydro-2H,6H-pyrido<2.1-b><1.3>oxazin 
• 108201-17-8 5-Ethyl-2,3-diphenyl-1-azabicyclo<4.3.0>non-2-en-4-on 
• 108201-32-7 6c-Ethyl-1,6b-diphenyl-2-thioxy-1,2,4,5,6,6a,6b,6c-octahydrocyclopropindolizin 
• 27300-27-2 1-(3,4,5,6-tetrahydro-2-pyridyl)-1-ethanone 
• 100-71-0 2-Ethylpyridine 
• 108201-23-6 9a-Ethyl-2-methoxy-3,4-diphenyl-7,8,9,9a-tetrahydro-2H,6H-pyrido<2.1-b><1.3>oxazin 

Relevant articles and documents

Stabilities of Stereoisomeric Imine Anions

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A Commercially Available and User-Friendly Catalyst for Hydroamination Reactions under Technical Conditions

The activity of a simple, commercially available copper salt, [Cu(NCMe)4](BF4) in intramolecular hydroamination reactions of alkynes and allenes is presented. Reactions were successfully carried out in technical acetonitrile in the presence of air. While attempts of alkene hydroamination failed, this catalyst was also found active in intermolecular aza-Michael reactions.

Characterization of three novel enzymes with imine reductase activity

Imine reductases (IRED) are promising catalysts for the synthesis of optically pure secondary cyclic amines. Three novel IREDs from Paenibacillus elgii B69, Streptomyces ipomoeae 91-03 and Pseudomonas putida KT2440 were identified by amino acid or structural similarity search, cloned and recombinantly expressed in E. coli and their substrate scope was investigated. Besides the acceptance of cyclic amines, also acyclic amines could be identified as substrates for all IREDs. For the IRED from P. putida, a crystal structure (PDB-code 3L6D) is available in the database, but the function of the protein was not investigated so far. This enzyme showed the highest apparent E-value of approximately Eapp = 52 for (R)-methylpyrrolidine of the IREDs investigated in this study. Thus, an excellent enantiomeric purity of >99% and 97% conversion was reached in a biocatalytic reaction using resting cells after 24 h. Interestingly, a histidine residue could be confirmed as a catalytic residue by mutagenesis, but the residue is placed one turn aside compared to the formally known position of the catalytic Asp187 of Streptomyces kanamyceticus IRED.