14624-88-5

Basic information

• Product Name: BIO-FARMA BF002424
• Synonyms: BIO-FARMA BF002424;1-BENZYL-2-METHYL-5-NITRO-1H-1,3-BENZIMIDAZOLE
• CAS NO: 14624-88-5
• Molecular Formula: C₁₅H₁₃N₃O₂
• Molecular Weight: 267.287
• Mol File: 14624-88-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 176-178°
• Appearance: /
• CAS DataBase Reference: BIO-FARMA BF002424(CAS DataBase Reference)
• NIST Chemistry Reference: BIO-FARMA BF002424(14624-88-5)
• EPA Substance Registry System: BIO-FARMA BF002424(14624-88-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 14624-88-5(Hazardous Substances Data)

Usage

General Description

BIO-FARMA BF002424 is a mixture of chemicals commonly used in the pharmaceutical and healthcare industries. The precise composition of the chemicals is proprietary information and therefore not publicly disclosed. However, the mixture likely contains various active pharmaceutical ingredients, excipients, and other substances necessary for formulating pharmaceutical products. These chemicals may have a variety of uses, such as in the production of tablets, capsules, suspensions, or other pharmaceutical dosage forms. They are likely subject to strict quality control and regulatory compliance to ensure their safety and efficacy for use in medical treatments.

Upstream product

• 1792-40-1 2-methyl-5-nitrobenzimidazole 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 615-15-6 2-Methyl-1H-benzimidazole 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 111055-37-9 1-benzyl-5-nitro-1H-benzimidazole-2-carboxaldehyde 
• 14624-97-6 1-benzyl-2-methyl-1H-benzimidazol-5-ylamine 
• 156212-98-5 3-(5-Amino-1-benzyl-1H-benzoimidazol-2-yl)-propionic acid ethyl ester 
• 156212-90-7 (E)-3-(1-Benzyl-5-nitro-1H-benzoimidazol-2-yl)-acrylic acid ethyl ester 
• 111055-40-4 1-Benzyl-5-hydroxy-2-methyl-1H-benzimidazole 
• 111055-39-1 1-Benzyl-5-methoxy-2-methyl-1H-benzimidazole 
• 111055-41-5 1-Benzyl-5-methoxy-1H-benzimidazole-2-carboxaldehyde 
• 111055-38-0 1-Benzyl-5-dimethylamino-2-methyl-1H-benzimidazole 
• 111055-42-6 1-Benzyl-5-dimethylamino-1H-benzimidazole-2-carboxaldehyde 
• 111055-26-6 1-Benzyl-5-methoxy-1H-benzoimidazole-2-carbaldehyde oxime 
• 111055-27-7 1-Benzyl-5-dimethylamino-1H-benzoimidazole-2-carbaldehyde oxime 
• 111073-85-9 1-Benzyl-5-nitro-1H-benzoimidazole-2-carbaldehyde oxime 
• 111055-24-4 1-Benzyl-5-methoxy-1H-benzoimidazole-2-carbaldehyde O-(2,4-dichloro-benzyl)-oxime 
• 111055-23-3 1-Benzyl-5-dimethylamino-1H-benzoimidazole-2-carbaldehyde O-(2,4-dichloro-benzyl)-oxime 

Relevant articles and documents

Synthesis and antitumor activity of 1-substituted-2-methyl-5-nitrobenzimidazoles

Different substituents were introduced in position 1 of 2-methyl-5(6)-nitro-1H-benzimidazole (2) in order to obtain different side chains having different heterocyclic compounds, for example, thiadiazoles (5-7), tetrazoles (8, 9a, b), triazoles (11-13), thiazoles (14a-e), triazines (10, 16, 17), and imidazoles (18a-c). The antitumor effect of compounds 1, 2, 2a, 4, 5, 7, 8, 9a, 10, 13, 14a, 15, 16, and 18c was studied against breast cancer (MCF7) and compounds 2 [IC50 = 4.52 μg] and 7 [IC50 = 8.29 μg] were found to be active.

Triazine-benzimidazole hybrids: Anticancer activity, DNA interaction and dihydrofolate reductase inhibitors

A new series of triazine-benzimidazole hybrids has been synthesized with different substitution of primary and secondary amines at one of the position of triazine in moderate to good yields. These compounds were evaluated for their inhibitory activities over 60 human tumor cell lines at one dose and five dose concentrations. Compounds 6b, 8 and 9 showed broad spectrum of antitumor activities with GI50 values of 9.79, 2.58 and 3.81 μM, respectively. DNA binding studies also indicated strong interaction properties of these compounds. These synthesized compounds also showed inhibition of mammalian dihydrofolate reductase (DHFR). Compound 6b was depicted as the most active member of DHFR inhibitor with IC50 value of 1.05 μM. Molecular modelling studies were used to identify the stabilized interactions of Compound 6b within the active site of enzyme for DHFR.

Synthesis and antimycotic activity of some benzyloxymino compounds

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