146257-39-8Relevant articles and documents
Scalable synthesis of vicinal quaternary stereocenters via the solid-state photodecarbonylation of a crystalline hexasubstituted ketone
Chang, Trevor Y.,Dotson, Jordan J.,Garcia-Garibay, Miguel A.
supporting information, p. 8855 - 8859 (2020/11/13)
We report the synthesis and stereospecific solid-state photodecarbonylation of a hexasubstituted ketone featuring six distinct α-substituents. The photoproduct of the solid-state transformation features vicinal all-carbon quaternary stereocenters. While reactions carried out in bulk powders and aqueous crystalline suspensions were complicated by secondary photochemistry of the primary photoproduct, optimal conditions provided good yields and recyclable starting material. Subsequent transformations of the α-substituents having orthogonal chemical reactivity illustrate the potential of this transformation toward constructing complex architectures.
FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF
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, (2009/06/27)
The present invention provides a fused heterocyclic derivative having a potent kinase inhibitory activity and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the specification, except a particular compound, or a salt thereof, and a pharmaceutical agent containing the compound or a prodrug thereof, which is a kinase (VEGFR, VEGFR2, PDGFR, Raf) inhibitor, an angiogenesis inhibitor, an agent for the prophylaxis or treatment of cancer, a cancer growth inhibitor or a cancer metastasis suppressor.
Selective Mono-methylation of Arylacetonitriles and Methyl Arylacetates by Dimethyl Carbonate
Selva, Maurizio,Marques, Carlos Alberto,Tundo, Pietro
, p. 1323 - 1328 (2007/10/02)
Both arylacetonitriles and methyl arylacetates react with dimethyl carbonate (DMC) (20 molar excess) at 180 - 200 deg C in the presence of K2CO3 to produce monomethylated 2-arylpropionitriles and methyl 2-arylpropionates, respectively, with a selectivity >99.5percent.The reaction, with wide application, proceeds by DMC acting as a methoxycarbonylating agent towards the ArCH-X anion (X = CN, CO2Me) and as a methylating agent to ArC-(CO2Me)X.DMC also proved to be the best solvent for such reactions.