146395-96-2

Basic information

• Product Name: Benzeneacetonitrile, 3,4-dichloro-α-[3-[(tetrahydro-2H-pyran-2-yl)oxy]propyl]-
• Synonyms: Benzeneacetonitrile, 3,4-dichloro-α-[3-[(tetrahydro-2H-pyran-2-yl)oxy]propyl]-
• CAS NO: 146395-96-2
• Molecular Weight: 328.238
• Mol File: 146395-96-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzeneacetonitrile, 3,4-dichloro-α-[3-[(tetrahydro-2H-pyran-2-yl)oxy]propyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile, 3,4-dichloro-α-[3-[(tetrahydro-2H-pyran-2-yl)oxy]propyl]-(146395-96-2)
• EPA Substance Registry System: Benzeneacetonitrile, 3,4-dichloro-α-[3-[(tetrahydro-2H-pyran-2-yl)oxy]propyl]-(146395-96-2)

Safety Data

• Hazardous Substances Data: 146395-96-2(Hazardous Substances Data)

Upstream product

• 33821-94-2 3-(tetrahydro-2H-pyran-2-yloxy)propyl bromide 
• 3218-49-3 3,4-dichloro-benzeneacetonitrile 
• 110-87-2 3,4-dihydro-2H-pyran 

Downstream Products

• 146395-97-3 4-Cyano-4-(3,4-dichloro-phenyl)-7-(tetrahydro-pyran-2-yloxy)-heptanoic acid ethyl ester 
• 167263-80-1 4-(3,4-dichloro-phenyl)-4-[3-(tetrahydro-pyran-2-yl-oxy)-propyl]-pyrrolidin-2-one 
• 167263-81-2 4-(3,4-dichloro-phenyl)-4-[3-(tetrahydro-pyran-2-yl-oxy)-propyl]-pyrrolidine 
• 214847-89-9 ethyl [3-cyano-3-(3,4-dichloro-phenyl)-6-(tetrahydro-pyran-2-yl-oxy)]-hexanoate 
• 172734-92-8 osanetant 
• 182621-57-4 {3-(3,4-Dichloro-phenyl)-3-[3-(4-methylamino-4-phenyl-piperidin-1-yl)-propyl]-piperidin-1-yl}-phenyl-methanone 
• 182621-50-7 Acetic acid 3-[3-(3,4-dichloro-phenyl)-2,6-dioxo-piperidin-3-yl]-propyl ester 
• 172734-92-8 (S)-(N)-(1-(3-(1-benzoyl-3(3,4-dichlorophenyl)piperidin-3-yl)propyl)-4-phenylpiperidin-4-yl)-N-methylacetamide 
• 182621-51-8 (+)-3-(3,4-dichlorophenyl)-3-(3-hydroxypropyl)-piperidine 
• 146396-02-3 {3-(3,4-Dichloro-phenyl)-3-[3-(tetrahydro-pyran-2-yloxy)-propyl]-piperidin-1-yl}-phenyl-methanone 
• 210545-35-0 1-Benzyl-5-(3,4-dichloro-phenyl)-5-[3-(tetrahydro-pyran-2-yloxy)-propyl]-piperidin-2-one 
• 210545-37-2 Methanesulfonic acid 3-[1-benzyl-3-(3,4-dichloro-phenyl)-6-oxo-piperidin-3-yl]-propyl ester 

Relevant articles and documents

A practical and scalable synthesis of SR 142801, a tachykinin NK3 antagonist

A practical and scalable total synthesis of tachykinin NK3 receptor antagonist SR 142801, (R)-N-[1-[3-[1-benzoyl-3-(3,4-dichlorophenyl)-3-piperidinyl]propyl]-4-phenyl-4 -piperidinyl]-N-methyl acetamide 1 is described. The absolute configuration of the key intermediate 7 was determined by single crystal X-ray crystallography, on the basis of which, the absolute configuration of SR 142801 should be (R)-(+), instead of the recently reported (S)-(+).

Substituted piperidines useful for the treatment of allergic diseases

The present invention relates to novel substituted piperidine derivatives of the formula STR1stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic diseases including: seasonal rhinitis, allergic rhinitis, and sinusitis.

SUBSTITUTED HETEROCYCLIC COMPOUNDS METHOD OF PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS IN WHICH THEY ARE PRESENT

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