1464-99-9

Basic information

• Product Name: 2,4-dichloro-N-(prop-2-yn-1-yl)benzamide
• Synonyms: 2,4-dichloro-N-(prop-2-yn-1-yl)benzamide
• CAS NO: 1464-99-9
• Molecular Weight: 228.078
• Mol File: 1464-99-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,4-dichloro-N-(prop-2-yn-1-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dichloro-N-(prop-2-yn-1-yl)benzamide(1464-99-9)
• EPA Substance Registry System: 2,4-dichloro-N-(prop-2-yn-1-yl)benzamide(1464-99-9)

Safety Data

• Hazardous Substances Data: 1464-99-9(Hazardous Substances Data)

Upstream product

• 50-84-0 2,4 dichlorobenzoic acid 
• 2450-71-7 Propargylamine 
• 89-75-8 2,4-dichlorobenzoyl chloride 

Relevant articles and documents

Glycosyl triazoles as novel insect β-N-acetylhexosaminidase OfHex1 inhibitors: Design, synthesis, molecular docking and MD simulations

The insect enzyme GH20 β-N-acetyl-D-hexosaminidase OfHex1 represents an important chitinolytic enzyme found in the agricultural pest Ostrinia furnacalis (Guenée) and inhibition of this enzyme has been considered a promising strategy for the development of eco-friendly pesticides. In this article, based on the structure of the catalytic domains of OfHex1, a series of novel glycosyl triazoles were designed and synthesized via Cu-catalyzed azide-alkyne [3+2] cycloaddition reaction. To investigate the potency and selectivity of these glycosyl triazoles, the inhibition activities towards OfHex1 and HsHexB (human β-N-acetylhexosaminidase B) were studied. Particularly compound 17c (OfHex1, Ki = 28.68 μM; HsHexB, Ki > 100 μM) exhibited a suitable activity and selectivity against OfHex1. Furthermore, the possible inhibitory mechanisms of 17c with OfHex1 were studied using molecular docking and MD simulations. The structure-activity relationship results as well as the formed binding patterns may provide promising insights into the further development of novel OfHex1 inhibitors.

Palladium-Catalyzed Cascade Difluoroalkylation/Cyclization of N-Propargylamides: Synthesis of Oxazoles and Oxazolines

A palladium-catalyzed process to construct oxazoles and oxazolines with broad functional-group tolerance has been developed, and the method introduces difluoromethyl groups into heterocycles in a one-pot fashion. This system uses a carbonyl oxygen as the acceptor for the addition of a vinylpalladium intermediate to achieve the cyclization. Oxazoline derivatives are generated as the Z-isomer with high stereoselectivity. Additionally, we validated the tentative mechanism of this reaction.