1464153-49-8Relevant articles and documents
Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia
Yang, Haiyan,Chennamaneni, Lohitha Rao,Ho, Melvyn Wai Tuck,Ang, Shi Hua,Tan, Eldwin Sum Wai,Jeyaraj, Duraiswamy Athisayamani,Yeap, Yoon Sheng,Liu, Boping,Ong, Esther Hq,Joy, Joma Kanikadu,Wee, John Liang Kuan,Kwek, Perlyn,Retna, Priya,Dinie, Nurul,Nguyen, Thuy Thi Hanh,Tai, Shi Jing,Manoharan, Vithya,Pendharkar, Vishal,Low, Choon Bing,Chew, Yun Shan,Vuddagiri, Susmitha,Sangthongpitag, Kanda,Choong, Meng Ling,Lee, May Ann,Kannan, Srinivasaraghavan,Verma, Chandra S.,Poulsen, Anders,Lim, Sharon,Chuah, Charles,Ong, Tiong Sin,Hill, Jeffrey,Matter, Alex,Nacro, Kassoum
, p. 4348 - 4369 (2018/05/14)
Chronic myeloid leukemia (CML) is a myeloproliferative disease caused by bcr-abl1, a constitutively active tyrosine kinase fusion gene responsible for an abnormal proliferation of leukemic stem cells (LSCs). Inhibition of BCR-ABL1 kinase activity offers long-term relief to CML patients. However, for a proportion of them, BCR-ABL1 inhibition will become ineffective at treating the disease, and CML will progress to blast crisis (BC) CML with poor prognosis. BC-CML is often associated with excessive phosphorylated eukaryotic translation initiation factor 4E (eIF4E), which renders LSCs capable of proliferating via self-renewal, oblivious to BCR-ABL1 inhibition. In vivo, eIF4E is exclusively phosphorylated on Ser209 by MNK1/2. Consequently, a selective inhibitor of MNK1/2 should reduce the level of phosphorylated eIF4E and re-sensitize LSCs to BCR-ABL1 inhibition, thus hindering the proliferation of BC LSCs. We report herein the structure-activity relationships and pharmacokinetic properties of a selective MNK1/2 inhibitor clinical candidate, ETC-206, which in combination with dasatinib prevents BC-CML LSC self-renewal in vitro and enhances dasatinib antitumor activity in vivo.
BICYCLIC HETEROCYCLIC DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF
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Page/Page column 85; 86, (2013/10/21)
The present invention relates to certain compounds (e.g., imidazopyrazine, imidazopyridine, imidazopyridazine and imidazpyrimidine compounds) that act as inhibitors of the MAP kinase interacting kinases MNK2a, MNK2b, MNK1a, and MNK1b. The present invention further relates to pharmaceutical compositions comprising these compounds, and to the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of diseases (e.g., proliferative diseases (e.g., cancer), inflammatory diseases, Alzheimer's disease), as well as methods of treating these diseases
