146464-91-7

Basic information

• Product Name: 6-Pteridinepropanoic acid, 2,4-diaMino-α-[4-(Methoxycarbonyl)phenyl]-α-2-propyn-1-yl-, Methyl ester
• Synonyms: 6-Pteridinepropanoic acid, 2,4-diaMino-α-[4-(Methoxycarbonyl)phenyl]-α-2-propyn-1-yl-, Methyl ester;6-Pteridinepropanoic acid, 2,4-diaMino-a-[4-(Methoxycarbonyl)phenyl]-a-2-propynyl-, Methyl ester;2,4-Diamino-alpha-[4-(methoxycarbonyl)phenyl]-alpha-2-propynyl-6-pteridinepropanoic acid methyl ester;6-Pteridinepropanoic acid, 2,4-diamino-.alpha.-[4-(methoxycarbonyl)phenyl]-.alpha.-2-propyn-1-yl-, methyl ester;Methyl 4-(2-((2,4-diaminopteridin-6-yl)methyl)-1-methoxy-1-oxopent-4-yn-2-yl)benzoate
• CAS NO: 146464-91-7
• Molecular Formula: C₂₁H₂₀N₆O₄
• Molecular Weight: 420.4213
• Mol File: 146464-91-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 669.1±65.0 °C(Predicted)
• Appearance: /
• Density: 1.387
• PKA: 5.54±0.10(Predicted)
• CAS DataBase Reference: 6-Pteridinepropanoic acid, 2,4-diaMino-α-[4-(Methoxycarbonyl)phenyl]-α-2-propyn-1-yl-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Pteridinepropanoic acid, 2,4-diaMino-α-[4-(Methoxycarbonyl)phenyl]-α-2-propyn-1-yl-, Methyl ester(146464-91-7)
• EPA Substance Registry System: 6-Pteridinepropanoic acid, 2,4-diaMino-α-[4-(Methoxycarbonyl)phenyl]-α-2-propyn-1-yl-, Methyl ester(146464-91-7)

Safety Data

• Hazardous Substances Data: 146464-91-7(Hazardous Substances Data)

Usage

General Description

"6-Pteridinepropanoic acid, 2,4-diamino-α-[4-(Methoxycarbonyl)phenyl]-α-2-propyn-1-yl-, Methyl ester" is a complex chemical compound derived from pteridinepropanoic acid with additional functional groups. 6-Pteridinepropanoic acid, 2,4-diaMino-α-[4-(Methoxycarbonyl)phenyl]-α-2-propyn-1-yl-, Methyl ester has a methoxy-carbonyl group attached to the fourth carbon in the phenyl group, a two-propyne group in the alpha position, and a 2,4-diamino group. In addition, it exists as a methyl ester of the original pteridinepropanoic acid compound. The specific properties, reactivities and applications of this compound are not provided. The understanding of such a complex compound would typically require a thorough review of its physical, chemical, and toxicological properties, including analytical methods. Therefore, such information might be included in broader databases or academic studies.

Upstream product

• 52853-40-4 6-bromomethyl-2,4-diaminopteridine hydrobromide 
• 146464-90-6 α-propargylhomoterephthalic acid dimethyl ester 
• 52787-14-1 methyl 4-(2-methoxy-2-oxoethyl)benzoate 
• 106-96-7 propargyl bromide 
• 1026380-17-5 dipropargyl homoterephthalic acid dimethyl ester 
• 67-56-1 methanol 
• 146464-92-8 4-(2-carboxy-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid 
• 59368-16-0 6-bromomethyl-pteridine-2,4-diamine 
• 501-89-3 4-(carboxymethyl)benzoic acid 

Downstream Products

• 146464-92-8 4-(2-carboxy-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid 
• 146464-93-9 4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid 
• 948552-65-6 C₂₃H₂₄N₆O₄ 
• 146464-95-1 pralatrexate 
• 146464-94-0 10-propargyl-10-deazaaminopterin diethyl ester 
• 374777-77-2 10-propargyl-10-deazaaminopterin dimethyl ester 
• 1320211-82-2 C₂₅H₂₇N₇O₅ 
• 1320211-79-7 C₂₅H₂₇N₇O₅ 
• 1445586-53-7 lithium 10-propargyl-4-deoxy-4-amino-10-deazapteroate 
• 1445586-50-4 10-propargyl-10-carboxy-4-deoxy-4-amino-10-deazapteroic acid sodium salt 
• 1445586-43-5 4-(3-((2,4-diaminopteridin-6-yl)methyl)-5-methylene-2-oxotetrahydrofuran-3-yl)benzoic acid 
• 1445586-44-6 potassium 10-propargyl-4-deoxy-4-amino-10-deazapteroate 
• 1548618-47-8 10-propargyl-10-carbomethoxy-4-deoxy-4-amino-10-deazapteroic acid methyl ester hydrobromide salt 

Relevant articles and documents

A suitable industrial production pula Qu Sha method for the preparation of

The invention relates to the field of pharmaceutical chemistry technology, and more specifically relates to an anticarcinogen 10-Propargyl-10-deazaaminopterin (Pralatrexate) and synthesis of an intermediate thereof. The invention has the advantages of simple operation, low contents of related impurities, easiness in purification of intermediate, thereby avoiding purification mode of column chromatography, and the invention can be applied to large scale production of Pralatrexate bulk drug as well as preparation and purification method of important intermediates.

PROCESS FOR PRALATREXATE

The present invention provides a novel process for the purification of alpha-propargylhomoterephthalic acid dimethyl ester substantially free of homoterephthalic acid dimethyl ester. The present invention also provides a novel process for the purification of pralatrexate.

PROCESSES AND INTERMEDIATES FOR PREPARING PRALATREXATE

Processes for preparing and purifying Pralatrexate are described in the present application, as well as intermediates in these processes, and salts and solid state forms of the Pralatrexate intermediates.