1464851-21-5

Basic information

• Product Name: (E)-6-amino-9-(prop-1-en-1-yl)-9H-purine
• CAS NO: 1464851-21-5
• Molecular Weight: 175.193
• Mol File: 1464851-21-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 415.6±48.0 °C(Predicted)
• Density: 1.39±0.1 g/cm3(Predicted)
• CAS DataBase Reference: (E)-6-amino-9-(prop-1-en-1-yl)-9H-purine(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-6-amino-9-(prop-1-en-1-yl)-9H-purine(1464851-21-5)
• EPA Substance Registry System: (E)-6-amino-9-(prop-1-en-1-yl)-9H-purine(1464851-21-5)

Safety Data

• Hazardous Substances Data: 1464851-21-5(Hazardous Substances Data)

Usage

General Description

(E)-6-amino-9-(prop-1-en-1-yl)-9H-purine is a chemical compound that belongs to the purine group and is also known as 6-Aminopurine. It is a derivative of adenine and is commonly found in nucleic acids like DNA and RNA. This chemical has a molecular formula of C7H8N6 and a molecular weight of 164.18 g/mol. It is a white to off-white crystalline powder and is sparingly soluble in water. (E)-6-amino-9-(prop-1-en-1-yl)-9H-purine is used in various biochemical research applications, including as a reagent in the study of enzymes, and as a precursor in the synthesis of nucleosides and pharmaceuticals. It has also been investigated for its potential pharmaceutical properties, including its anti-cancer and antiviral activities.

Upstream product

• 4121-39-5 9-allyl-9H-adenine 
• 66224-66-6 adenine 
• 87-42-3 6-chloropurine 
• 1258274-91-7 6-chloro-7-(3-methylbut-2-en-1-yl)-7H-purine 
• 520-54-7 7-(3-methylbut-2-en-1-yl)-7H-purin-6-amine 
• 169558-41-2 6-chloro-9-(3-methylbut-2-en-1-yl)-9H-purine 
• 5122-38-3 9-(3-methylbut-2-en-1-yl)-9H-purin-6-amine 
• 1164283-79-7 (E)-6-chloro-9-cinnamyl-9H-purine 
• 1013022-27-9 (E)-9-cinnamyl-9H-purin-6-amine 
• 1446486-34-5 1-(adenin-9-yl)propan-2-yl methanesulfonate 
• 590-13-6 (Z)-1-propenyl bromide 
• 6034-68-0 N⁶-acetyladenine 
• 1530-32-1 ethyltriphenylphosphonium bromide 

Relevant articles and documents

Preparation method of tenofovir intermediate

The invention discloses a preparation method of a tenofovir intermediate. The preparation method comprises the following steps: 1, contacting and reacting adenine with (Z)-1-halopropylene in an organic solvent in the presence of hexamethylphosphoramide to obtain (Z)-9-propenyladenine; and 2, reacting the (Z)-9-propenyladenine with metachloroperbenzoic acid under the catalysis of a chiral catalyst to obtain the tenofovir intermediate (R)-9-(2-hydroxypropyl)adenine, wherein the chiral catalyst is D-(-)-tartaric acid. The raw materials of the preparation method of the tenofovir intermediate are easy to obtain, so cost control is facilitated; the target product is obtained through introducing relative configuration Z shape alkene and carrying out selective oxidation without using a large amount of a chiral compound, so the product selectivity is good, and the yield is high; and the method has the advantages of no special strict conditions, mild reaction conditions, and convenience in amplified production operation and industrial application promotion.

Synthesis of (E)-9-(Propen-1-yl)-9 H-adenine, a mutagenic impurity in tenofovir disoproxil fumarate

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