146549-16-8Relevant articles and documents
Non-destructive Cleavage of N-Acylsultams Under Neutral Conditions: Preparation of Enantiomerically, Pure Fmoc-Protected α-Amino Acids
Oppolzer, Wolfgang,Lienard, Philippe
, p. 2572 - 2582 (2007/10/02)
Heating diastereoisomerically pure N-acylsultams 3 or 4 with allyl alcohol/Ti(OR)4 efficiently yields sultams 1 or 2 and allyl esters 5.Esters 5 are hydrolyzed under nonbasic conditions in the presence of Wilkinson's catalyst to give enantiomerically and diastereoisomerically pure carboxylic acids 7.A series of carbonyl-(Fmoc)-protected amino acids 14 were thus prepared from N-acylsultams 12.
