146575-63-5Relevant articles and documents
Spiro-benzopyran derivatives and useful for treating asthma and hypertension
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, (2008/06/13)
The present invention relates to novel benzopyran derivatives of formula(I) which have exellent effectiveness in the treatment of asthma as well as hypertension. STR1 wherein R1 is --CN, --NO2, --OCX1 X2 X3, --NH2, --NHSO2 RA, STR2 --SO2 RC or --SO2 NRC RD wherein X1, X2 and X3 are, each independently, F, Cl or H, except for that X1, X2 and X3 may not be hydrogen atom simulaneously; RA and RB are, each independently, a hydrogen atom, or a C1-6 alkyl group or an optionally substituted phenyl group with a halogen atom, or a straight or branched C1-3 alkyl group; and RC and RD are, each independently, a hydrogen atom or a C1-6 alkyl group or an optionally substituted phenyl group with a halogen atom, or a straight or branched C1-3 alkyl group; R2 is a C1-4 straight or branched alkyl group; R3 is a C1-4 straight or branched alkyl group, STR3 wherein RG and RH are, each independently, a C1-6 alkyl group or optionally substituted phenyl group with a halogen atom, or a straight or branched C1-3 alkyl group, A and B are, each independently, S or O; and Z is a C1-3 straight or branched alkyl group; X is N or N→O.
Novel benzopyran derivatives and processes for the preparation thereof
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, (2008/06/13)
The present invention relates to novel benzopyran derivatives of formula(I) which have superior selectivity in the treatment of hypertension by lowering blood pressure with a relaxation activity on vascular smooth muscle. The present invention also relate
