146579-01-3

Basic information

• Product Name: ((4S,6R)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid methyl ester
• Synonyms: ((4S,6R)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid methyl ester
• CAS NO: 146579-01-3
• Molecular Weight: 475.56
• Mol File: 146579-01-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ((4S,6R)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: ((4S,6R)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid methyl ester(146579-01-3)
• EPA Substance Registry System: ((4S,6R)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid methyl ester(146579-01-3)

Safety Data

• Hazardous Substances Data: 146579-01-3(Hazardous Substances Data)

Upstream product

• 121660-11-5 2-cyclopropyl-4-(4-fluorophenyl)-3-(hydroxymethyl)quinoline 
• 154057-56-4 3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)-quinoline 
• 109583-02-0 methyl (3S,5R,6E)-7-phenyl-3,5-isopropylidenedioxy-6-heptenoate 
• 109519-24-6 methyl (3S,5R)-3,5-isopropylidenedioxy-6-oxohexanoate 
• 146578-99-6 <2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl>methyl(diphenyl)phosphine oxide 

Downstream Products

• 141750-59-6 (3S,5R,6E)-7-<2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl>-3,5-dihydroxy-6-heptenoic acid ,15-lactone 

Relevant articles and documents

Synthesis of artificial HMG-CoA reductase inhibitors based on the olefination strategy

Synthetic methods were studied for optically active 6-oxo-3,5-isopropylidenedioxyhexanoate esters (4), which could be used as a key precursor of various kinds of artificial analogs of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. An enantiomer (+)-4 was prepared by asymmetric reduction of β,δ-diketo esters derived from the Taber's alcohol or L-tartrate followed by a series of chemical transformations, and the desired enantiomer (-)-4 was prepared by the same asymmetric reduction starting from D-tartrate. The key intermediate (-)-4 was finally converted into a highly potent HMG-CoA reductase inhibitor, NK-104.