14663-26-4 Usage
Description
1-((E)-[5-(4-chlorophenyl)furan-2-yl]methylideneamino)imidazolidine-2,4-dione is a chemical compound that serves as an intermediate in the synthesis of Azimilide Dihydrochloride (A926950), a type III potassium channel blocker agent. 1-((E)-[5-(4-chlorophenyl)furan-2-yl]methylideneamino)imidazolidine-2,4-dione plays a crucial role in the development of medications for the treatment of various cardiac conditions.
Uses
1. Used in Pharmaceutical Industry:
1-((E)-[5-(4-chlorophenyl)furan-2-yl]methylideneamino)imidazolidine-2,4-dione is used as an intermediate for the synthesis of Azimilide Dihydrochloride, which is an oral type III potassium channel blocker agent. It is effective in blocking both the rapid activating component and the slow activating component of the delayed rectifier potassium current, making it a valuable compound for the development of medications to treat supraventricular and ventricular tachyarrhythmia.
2. Used in Cardiology:
1-((E)-[5-(4-chlorophenyl)furan-2-yl]methylideneamino)imidazolidine-2,4-dione contributes to the development of Azimilide, a medication that has demonstrated efficacy and safety in the treatment of supraventricular and ventricular tachyarrhythmia. 1-((E)-[5-(4-chlorophenyl)furan-2-yl]methylideneamino)imidazolidine-2,4-dione is essential for creating a drug that can help manage and prevent life-threatening cardiac conditions.
3. Used in Clinical Trials:
1-((E)-[5-(4-chlorophenyl)furan-2-yl]methylideneamino)imidazolidine-2,4-dione is also utilized in the ongoing worldwide multicenter trial for the prevention of sudden cardiac death in patients after myocardial infarction. The compound's role in the synthesis of Azimilide makes it a vital component in the research and development of potential life-saving treatments for patients at high risk of sudden cardiac death.
Check Digit Verification of cas no
The CAS Registry Mumber 14663-26-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,6,6 and 3 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 14663-26:
(7*1)+(6*4)+(5*6)+(4*6)+(3*3)+(2*2)+(1*6)=104
104 % 10 = 4
So 14663-26-4 is a valid CAS Registry Number.
14663-26-4Relevant articles and documents
Synthesis of arylfuran derivatives as potential antibacterial agents
Andrade, Marina M. S.,Protti, ícaro F.,Maltarollo, Vinícius G.,da Costa, Ygor F. G.,de Moraes, Wesley G.,Moreira, Nicole F.,Garcia, Giovana G.,Caran, Gabriel F.,Ottoni, Flaviano M.,Alves, Ricardo J.,Moreira, Carolina P. S.,Martins, Helen R.,Alves, Maria Silvana,de Oliveira, Renata B.
, p. 1074 - 1086 (2021/02/26)
Bacterial infections represent a serious health care problem mainly due to the misuse and overuse of antibiotics, with consequent emergence of multidrug resistant bacterial strains. Then, because the urgent need to find novel and alternative antibacterial agents, the present work focuses on the synthesis of arylfuran derivatives with potential antimicrobial activity. Eighteen arylfuran derivatives were synthesized and evaluated for their antibacterial activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Among them, seven compounds containing an amino group in their structure showed activity, with compound 24 being the most effective against both Gram-negative (E. coli, MIC = 49 μM) and Gram-positive (S. aureus, MIC = 98 μM) bacteria, besides having exhibited a modest activity against P. aeruginosa (MIC = 770 μM). In addition, based on in silico studies, this is a druglike compound since it does not violate any rules for predicting oral bioavailability. In this context, the significant antibacterial potential and the low similarity with known antibiotics indicate the innovative aspect of compound 24.