146724-32-5 Usage
Description
Methyl 1H-pyrrolo[3,2-h]quinoline-2-carboxylate is a chemical compound with the molecular formula C14H11NO2. It is an ester derivative of 1H-pyrrolo[3,2-h]quinoline-2-carboxylic acid and is characterized by its fused ring structure. Methyl 1H-pyrrolo[3,2-h]quinoline-2-carboxylate is commonly used in organic synthesis and pharmaceutical research due to its unique chemical properties, making it a valuable intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. Its structure and reactivity also make it a useful tool in the study of organic reactions and the development of new chemical methodologies.
Uses
Used in Pharmaceutical Research:
Methyl 1H-pyrrolo[3,2-h]quinoline-2-carboxylate is used as a building block for the preparation of various biologically active molecules. Its unique structure and reactivity contribute to the development of new pharmaceuticals with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, Methyl 1H-pyrrolo[3,2-h]quinoline-2-carboxylate serves as an important intermediate. Its chemical properties allow for its use in the synthesis of a wide range of compounds, facilitating the creation of new molecules with various applications.
Used in Agrochemical Development:
Methyl 1H-pyrrolo[3,2-h]quinoline-2-carboxylate is also utilized in the development of agrochemicals. Its role as an intermediate aids in the synthesis of compounds that can be used in agricultural applications, such as pesticides or herbicides.
Used in the Study of Organic Reactions:
Methyl 1H-pyrrolo[3,2-h]quinoline-2-carboxylate is used as a tool in the study of organic reactions. Its unique structure and reactivity provide insights into the mechanisms of various chemical processes, contributing to the advancement of organic chemistry and the development of new methodologies.
Check Digit Verification of cas no
The CAS Registry Mumber 146724-32-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,7,2 and 4 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 146724-32:
(8*1)+(7*4)+(6*6)+(5*7)+(4*2)+(3*4)+(2*3)+(1*2)=135
135 % 10 = 5
So 146724-32-5 is a valid CAS Registry Number.
InChI:InChI=1/C13H10N2O2/c1-17-13(16)10-7-9-5-4-8-3-2-6-14-11(8)12(9)15-10/h2-7,15H,1H3
146724-32-5Relevant articles and documents
2-Substituted 1H-pyrrolo [3,2-h] quinoline derivatives: Synthesis and aspects of their biological activity
Grazia Ferlin,Chiarelotto,Baccichetti,Carlassare,Toniolo,Bordin
, p. 1513 - 1528 (2007/10/02)
Certain 2-substituted 1H-pyrrolo [3,2-h] quinolines have been prepared and their biological activity in mammalian cells and in some microrganisms have been studied. These compounds represent a simplified ellipticine heterocyclic moiety: in addition they have a different ring condensation, leading to an angular molecular structure instead of a linear one. In mammalian cells all compounds appeared to be able of inducing an antiproliferative effect and an extensive DNA fragmentation, similarly to ellipticine, even if to a reduced extent. The new derivatives behaved in a comparable way also on some microrganisms, such as T2 bacteriophage (which appears to be less sensitive than mammalian cells) and in mutagenesis tests carried out with E. coli WP2 TM9 and S. typhimurium TA 98, which are reverted by base substitution and frame-shift mutagens, respectively. Similarly to the reference compound, all ellipticine analogues appeared to be no mutagenic. The obtained results suggest that they induce the antiproliferative activity in mammalian cells mainly as topoisomerase inhibitors, similarly to ellipticine itself. Therefore, they represent an interesting model to design new potential anticancer drugs.