146724-86-9

Basic information

• Product Name: MAHMA NONOATE
• Synonyms: MAHMA/NO;MAHMA NONOATE;METHYLAMINE HEXAMETHYLENE METHYLAMINE NONOATE;1-HYDROXY-2-OXO-3-(N-METHYL-6-AMINOHEXYL)-3 METHYL-1-TRIAZENE;6-(2-HYDROXY-1-METHYL-2-NITROSOHYDRAZINO)-N-METHYL-1-HEXANAMINE;NOC-9;(Z)-1-[N-METHYL-N-[6-(N-METHYLAMMONIOHEXYL)AMINO]]DIAZEN-1-IUM-1,2-DIOLATE;noc-9crystalline
• CAS NO: 146724-86-9
• Molecular Formula: C8H20N4O2
• Molecular Weight: 204.27
• Mol File: 146724-86-9.mol
• Article Data: 0

Chemical Properties

• Melting Point: 102-108 °C
• Boiling Point: 301.7°Cat760mmHg
• Flash Point: 136.3°C
• Appearance: /
• Density: 1.1g/cm³
• Vapor Pressure: 0.000101mmHg at 25°C
• Storage Temp.: −70°C
• PKA: 0.45±0.69(Predicted)
• CAS DataBase Reference: MAHMA NONOATE(CAS DataBase Reference)
• NIST Chemistry Reference: MAHMA NONOATE(146724-86-9)
• EPA Substance Registry System: MAHMA NONOATE(146724-86-9)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 146724-86-9(Hazardous Substances Data)

Usage

Description

MAHMA NONOate, a diazeniumdiolate quick-releasing NO donor, is a white to off-white crystalline solid that serves as a nitric oxide (NO) donor. It spontaneously dissociates in a pH-dependent, first-order process, with a half-life of 1 minute at 37°C and 3 minutes at 22-25°C (pH 7.4), releasing 2 moles of NO per mole of the parent compound.

Uses

Used in Pharmaceutical Industry:
MAHMA NONOate is used as a NO donor for various pharmaceutical applications. Its ability to release nitric oxide makes it a valuable compound in the development of drugs targeting conditions that can benefit from enhanced NO production, such as cardiovascular diseases and certain inflammatory disorders.
Used in Research Applications:
In the field of scientific research, MAHMA NONOate is utilized as a NO donor to study the effects of nitric oxide on various biological processes. This includes investigating the role of NO in cell signaling, its involvement in the immune response, and its potential as a therapeutic agent for various diseases.
Used in Drug Delivery Systems:
MAHMA NONOate can be employed in the development of drug delivery systems designed to enhance the bioavailability and targeted delivery of nitric oxide. This may involve the use of nanoparticles or other carriers to improve the compound's stability, solubility, and release profile, ultimately enhancing its therapeutic potential.
Used in Diagnostic Applications:
As a NO donor, MAHMA NONOate can also be utilized in diagnostic applications to assess the role of nitric oxide in various physiological and pathological conditions. This may involve monitoring NO levels in biological samples or using the compound as a contrast agent in imaging techniques to visualize NO-related processes in the body.

InChI:InChI=1/C8H20N4O2/c1-9-7-5-3-4-6-8-11(2)12(14)10-13/h9,14H,3-8H2,1-2H3/p+1