14673-56-4

Basic information

• Product Name: Acetone 4-phenyl thiosemicarbazone
• Synonyms: Acetone 4-phenyl thiosemicarbazone
• CAS NO: 14673-56-4
• Molecular Formula: C₁₀H₁₃N₃S
• Molecular Weight: 207.2953
• Mol File: 14673-56-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 306.6°Cat760mmHg
• Flash Point: 139.2°C
• Appearance: /
• Density: 1.11g/cm³
• Vapor Pressure: 0.000763mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: Acetone 4-phenyl thiosemicarbazone(CAS DataBase Reference)
• NIST Chemistry Reference: Acetone 4-phenyl thiosemicarbazone(14673-56-4)
• EPA Substance Registry System: Acetone 4-phenyl thiosemicarbazone(14673-56-4)

Safety Data

• Hazardous Substances Data: 14673-56-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H13N3S/c1-8(2)12-13-10(14)11-9-6-4-3-5-7-9/h3-7H,1-2H3,(H2,11,13,14)

Upstream product

• 62-53-3 aniline 
• 1752-30-3 Acetone thiosemicarbazone 
• 108-88-3 toluene 
• 5351-69-9 4-Phenyl-3-thiosemicarbazide 
• 67-64-1 acetone 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 865316-65-0 3-phenyl-thiazolidine-2,4-dione-2-isopropylidenehydrazone 
• 110152-93-7 (Z)-3,4-diphenyl-2-(propan-2-ylidenehydrazono)-2,3-dihydrothiazole 
• 67618-48-8 2-isopropylidenehydrazono-3-phenyl-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester 
• 25688-07-7 2,5-Dihydro-5,5-dimethyl-2-(phenylimino)-1,3,4-thiadiazole 
• 3161-76-0 2-isopropylidenehydrazono-4-methyl-3-phenyl-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester 
• 89578-94-9 C₁₁H₁₅N₃S 
• 21076-38-0 1-isopropyl-4-phenyl thiosemicarbazide 
• 25687-97-2 4,5-Dihydro-3,3-dimethyl-4-phenyl-3H-1,2,4-triazole-5-thione 
• 89579-03-3 2,2-Dimethyl-5-phenylamino-[1,3,4]thiadiazole-3-carboxylic acid phenylamide 
• 95881-68-8 1,1-Dimethyl-3-[(E)-phenylimino]-[1,2,4]triazolo[1,2-c][1,3,4]thiadiazole-5,7-dione 
• 88614-17-9 3-isopropylideneamino-2-phenylimino-1,3-thiazolidin-4-one 
• 5533-44-8 N⁵-phenyl-tetrazole-1,5-diamine 
• 80269-73-4 6-chloro-2,2-dimethyl-4-phenyl-1-thia-4-azaspiro<2.3>hexan-5-one 
• 80269-74-5 4-isopropylidene-2-oxo-1,3,3-triphenylazetidine 

Relevant articles and documents

Square planar Ni(ii) complexes of acetone: N 4-phenyl-thiosemicarbazone and in situ generated benzoyl thiosemicarbazide ligands: Synthesis, spectral and structural characterizations, thermal behaviour and electrochemical studies

Two novel square planar complexes [Ni(Hapt)2] (1) and [Ni(btsc)] (2) have been synthesized from acetone N4-phenyl-thiosemicarbazone (Hapt) and benzoyl-3-thiosemicarbazide (Hbtsc) by the reaction of nickel(ii) salt. The ligand and complexes have been characterized by various physicochemical methods. Complexes 1 and 2 crystallize in the monoclinic and orthorhombic systems with space group C2/c and Pbcn, respectively. In complexes 1 and 2 the nickel centre is coordinated through the nitrogen and sulphur atoms forming a square planar geometry. Complexes 1 and 2 are stabilized via various types of intermolecular interactions. The course of the thermal degradations of complexes 1 and 2 has been investigated by TGA which indicated that a metal sulphide/oxide is formed as the final residue. Cyclic voltammetric studies show that complex 1 exhibits a reversible Ni(ii)/Ni(iii) redox process at 0.525 V (E1/2 value at 20 mV s-1) while complex 2 shows reversible redox behavior with an E1/2 value of 0.43 V. Furthermore, efficient electrocatalytic properties of complexes 1 and 2 toward the oxidation of hydrazine and methanol are demonstrated after immobilizing the complexes into Nafion films. The electrocatalytic properties may find applications in industry, in methanol sensing and in methanol fuel cells.

Synthesis, characterization, and anticancer activity of a series of ketone-N4-substituted thiosemicarbazones and their ruthenium(II) arene complexes

A series of ketone-N4-substituted thiosemicarbazone (TSC) compounds (L1-L9) and their corresponding [(η6-p-cymene)Ru II(TSC)Cl]+/0 complexes (1-9) were synthesized and characterized by NMR, IR, elemental analysis, and HR-ESI-mass spectrometry. The molecular structures of L4, L9, 1-6, and 9 were determined by single-crystal X-ray diffraction analysis. The compounds were further evaluated for their in vitro antiproliferative activities against the SGC-7901 human gastric cancer, BEL-7404 human liver cancer, and HEK-293T noncancerous cell lines. Furthermore, the interactions of the compounds with DNA were followed by electrophoretic mobility spectrometry studies.