146748-28-9

Basic information

• Product Name: diphenylmethyl 7β-tert-butoxycarbonylamino-3-(4-pyridyl)thiomethyl-3-cephem-4-carboxylate
• Synonyms: diphenylmethyl 7β-tert-butoxycarbonylamino-3-(4-pyridyl)thiomethyl-3-cephem-4-carboxylate
• CAS NO: 146748-28-9
• Molecular Weight: 589.736
• Mol File: 146748-28-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: diphenylmethyl 7β-tert-butoxycarbonylamino-3-(4-pyridyl)thiomethyl-3-cephem-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: diphenylmethyl 7β-tert-butoxycarbonylamino-3-(4-pyridyl)thiomethyl-3-cephem-4-carboxylate(146748-28-9)
• EPA Substance Registry System: diphenylmethyl 7β-tert-butoxycarbonylamino-3-(4-pyridyl)thiomethyl-3-cephem-4-carboxylate(146748-28-9)

Safety Data

• Hazardous Substances Data: 146748-28-9(Hazardous Substances Data)

Upstream product

• 4556-23-4 pyridine-4-thiol 
• 112028-91-8 3-chloromethyl-7β-tert-butyloxycarbonylamino-3-cephem-4-carboxylic acid diphenylmethyl ester 

Downstream Products

• 288379-99-7 7β-[2-(Z)-(2-aminothiazol-4-yl)-2-(trityloxyimino)acetamido]-3-(4-pyridyl)thiomethyl-3-cephem-4-carboxylic acid 

Relevant articles and documents

Orally active cephalosporins. Part 2: Synthesis, structure-activity relationships and oral absorption of cephalosporins having a C-3 pyridyl side chain

A series of 7β-[(Z)-2-(2-aminothiazol-4-yl)-2- hydroxyiminoacetamido]cephalosporins having a pyridine ring connected through various spacer moieties at the C-3 position was designed and synthesized and evaluated for antibacterial activity and oral absorption in rats. All compounds showed potent antibacterial activity against Staphylococcus aureus, whereas antibacterial activity against Gram-negative bacteria was markedly influenced by the spacer moiety between the pyridine and cephem nucleus. Oral absorption was influenced by the position of the pyridine nitrogen as well as by the spacer moiety. Among these compounds, FR86830 (14), having a 4- pyridylmethylthio moiety at the C-3 position, showed the most well balanced activity and moderate oral absorption. (C) 2000 Elsevier Science Ltd.