1467668-53-6

Basic information

• Product Name: 2-(3-aminophenyl)-5,6,7-trimethoxy-4H-chromen-4-one
• Synonyms: 2-(3-aminophenyl)-5,6,7-trimethoxy-4H-chromen-4-one
• CAS NO: 1467668-53-6
• Molecular Weight: 327.337
• Mol File: 1467668-53-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(3-aminophenyl)-5,6,7-trimethoxy-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-aminophenyl)-5,6,7-trimethoxy-4H-chromen-4-one(1467668-53-6)
• EPA Substance Registry System: 2-(3-aminophenyl)-5,6,7-trimethoxy-4H-chromen-4-one(1467668-53-6)

Safety Data

• Hazardous Substances Data: 1467668-53-6(Hazardous Substances Data)

Upstream product

• 22248-14-2 6-hydroxy-2,3,4-trimethoxyacetophenone 
• 642-71-7 3,4,5-trimethoxyphenol 
• 35418-05-4 (E)-3-nitrocinnamic acid chloride 
• 555-68-0 (E)-3-Nitrocinnamic acid 
• 1348034-59-2 5,6,7-trimethoxy-2-(3-nitrophenyl)-4H-chromen-4-one 

Downstream Products

• 1467668-62-7 N-(3-(5,6,7-trimethoxy-4-oxo-4H-chromen-2-yl)phenyl)methanesulfonamide 
• 1467668-54-7 N-(3-(5,6,7-trimethoxy-4-oxo-4H-chromen-2-yl)phenyl)-benzenesulfonamide 
• 1467668-59-2 4-bromo-N-(3-(5,6,7-trimethoxy-4-oxo-4H-chromen-2-yl)phenyl)benzenesulfonamide 
• 1467668-60-5 4-nitro-N-(3-(5,6,7-trimethoxy-4-oxo-4H-chromen-2-yl)phenyl)benzenesulfonamide 

Relevant articles and documents

Natural products hybrids: 3,5,4′-Trimethoxystilbene-5,6,7-trimethoxyflavone chimeric analogs as potential cytotoxic agents against diverse human cancer cells

Cancer still represents a major global health problem. All currently available anticancer agents have disadvantages like resistance or side effects. Therefore, introduction of novel anticancer agents is needed. Intrigued by the high success rate for natural products-based drug discovery, we designed and synthesized antiproliferative chemical entities as hybrids of two natural products; 3,5,4′-trimethoxystilbene and 5,6,7-trimethoxyflavone. To probe the spectrum of the synthesized compounds, in vitro evaluation was conducted against nine panels representing major cancer diseases. The results revealed the hybrid analogs 4f, 4h, 4k and 4q as promising broad-spectrum anticancer lead compounds eliciting high growth inhibition of several cell lines representing multiple cancers diseases. Evaluation of the promising lead compounds against normal human cell lines suggested a selective cytotoxic effect on cancer cells. Mechanistic investigation of the cytotoxic activity of compound 4f in human cervical cancer HeLa cells showed that it triggers cell death through induction of apoptosis. As a whole, this study presents the natural products hybrid analogs 4f, 4h, 4k and 4q as potential lead compounds for further development of novel anticancer therapeutics.