14677-21-5

Basic information

• Product Name: 4,5-Diphenylisoxazole
• Synonyms: 4,5-Diphenylisoxazole
• CAS NO: 14677-21-5
• Molecular Formula: C₁₅H₁₁NO
• Molecular Weight: 221.2539
• Mol File: 14677-21-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 353.2°Cat760mmHg
• Flash Point: 126.8°C
• Appearance: /
• Density: 1.128g/cm³
• Vapor Pressure: 7.4E-05mmHg at 25°C
• Refractive Index: 1.586
• CAS DataBase Reference: 4,5-Diphenylisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-Diphenylisoxazole(14677-21-5)
• EPA Substance Registry System: 4,5-Diphenylisoxazole(14677-21-5)

Safety Data

• Hazardous Substances Data: 14677-21-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H11NO/c1-3-7-12(8-4-1)14-11-16-17-15(14)13-9-5-2-6-10-13/h1-11H

Upstream product

• 140866-59-7 1,2-diphenyl-3-(N,N-dimethylamino)-2-propen-1-one 
• 299215-99-9 4,5-bis(2-iodophenyl)isoxazole 
• 299215-98-8 4,5-bis(2-bromophenyl)isoxazole 
• 89959-83-1 1,3-diphenyl-2,3-bis(tosyloxy)-1-oxopropane 

Downstream Products

• 5415-07-6 3-oxo-2,3-diphenyl-propionitrile 

Relevant articles and documents

The chemistry of α,β-ditosyloxy ketones: A new and convenient route to 4,5-diarylisoxazoles from α,β-chalcone ditosylates

The reaction of α,β-chalcone ditosylates with hydroxyl-amine hydrochloride under suitable conditions leads to a 1,2-aryl shift, thereby providing a new route to 4,5-disubstituted isoxazoles. Georg Thieme Verlag Stuttgart. New York.

A convenient one-pot preparative method for 4,5-diarylisoxazoles involving amine exchange reactions

4,5-Diarylisoxazoles 1 are efficiently prepared by submitting enaminones 2, readily obtained from deoxybenzoins 3, to oximation conditions. This conversion implies an uncommon amine group exchange reaction. Preparation of 4-isoxazolines 5 and ring-opening transformations to β-keto nitriles 4 and 1,3-amino alcohol derivatives 7 are also described.