14678-48-9 Usage
Description
Methyl 3-amino-2-methylpropanoate is a chemical compound with the molecular formula C5H11NO2. It is an amino acid derivative that is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceuticals. It is also used in organic synthesis as a chiral auxiliary and as a reagent for the preparation of various heterocyclic compounds. Methyl 3-amino-2-methylpropanoate is a white to off-white crystalline solid that is soluble in polar organic solvents such as methanol and ethanol. It is important to handle and store this compound in a well-ventilated area, away from heat and ignition sources, as it may pose a fire hazard.
Uses
Used in Pharmaceutical Industry:
Methyl 3-amino-2-methylpropanoate is used as a building block for the synthesis of various drugs and pharmaceuticals. Its unique structure and reactivity make it a valuable component in the development of new medications.
Used in Organic Synthesis:
Methyl 3-amino-2-methylpropanoate is used as a chiral auxiliary in organic synthesis, helping to control the stereochemistry of reactions and produce enantiomerically pure compounds.
Used in Heterocyclic Compound Preparation:
Methyl 3-amino-2-methylpropanoate is used as a reagent for the preparation of various heterocyclic compounds, which are important in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 14678-48-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,6,7 and 8 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 14678-48:
(7*1)+(6*4)+(5*6)+(4*7)+(3*8)+(2*4)+(1*8)=129
129 % 10 = 9
So 14678-48-9 is a valid CAS Registry Number.
14678-48-9Relevant articles and documents
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Beckett,A.H. et al.
, p. 1386 - 1388 (1962)
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Discovery of Benzotriazolo[4,3-d][1,4]diazepines as Orally Active Inhibitors of BET Bromodomains
Taylor, Alexander M.,Vaswani, Rishi G.,Gehling, Victor S.,Hewitt, Michael C.,Leblanc, Yves,Audia, James E.,Bellon, Steve,Cummings, Richard T.,Co?té, Alexandre,Harmange, Jean-Christophe,Jayaram, Hari,Joshi, Shivangi,Lora, Jose M.,Mertz, Jennifer A.,Neiss, Adrianne,Pardo, Eneida,Nasveschuk, Christopher G.,Poy, Florence,Sandy, Peter,Setser, Jeremy W.,Sims, Robert J.,Tang, Yong,Albrecht, Brian K.
, p. 145 - 150 (2016/03/01)
Inhibition of the bromodomains of the BET family, of which BRD4 is a member, has been shown to decrease myc and interleukin (IL) 6 in vivo, markers that are of therapeutic relevance to cancer and inflammatory disease, respectively. Herein we report substituted benzo[b]isoxazolo[4,5-d]azepines and benzotriazolo[4,3-d][1,4]diazepines as fragment-derived novel inhibitors of the bromodomain of BRD4. Compounds from these series were potent and selective in cells, and subsequent optimization of microsomal stability yielded representatives that demonstrated dose- and time-dependent reduction of plasma IL-6 in mice.
MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF
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Page/Page column 156, (2012/06/30)
Disclosed are compounds, pharmaceutical compositions containing the compounds, and the uses of the compounds and compositions as modulators of histone methyltransferases, and for treating diseases influenced by modulation of histone methyltransferase activity.