14678-81-0 Usage
Description
1-ACETYL-2-METHYLBENZIMIDAZOLE is an organic compound with the molecular formula C10H10N2O. It is a derivative of benzimidazole, featuring an acetyl group at the 1st position and a methyl group at the 2nd position. 1-ACETYL-2-METHYLBENZIMIDAZOLE is known for its ability to interact with various receptors, including serotonin and dopamine receptors.
Uses
Used in Pharmaceutical Industry:
1-ACETYL-2-METHYLBENZIMIDAZOLE is used as an impurity in Filbanserin (F336750), a drug that acts as an agonist of the serotonin-5HT1A receptor and an antagonist of the 5-HT2A receptor. It is utilized for the treatment of hypoactive sexual desire disorder in females.
1-ACETYL-2-METHYLBENZIMIDAZOLE is also used as a ligand for binding to dopamine receptors, with Ki values ranging from 4-24 nM. This property makes it a potential candidate for the development of new drugs targeting dopamine-related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 14678-81-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,6,7 and 8 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 14678-81:
(7*1)+(6*4)+(5*6)+(4*7)+(3*8)+(2*8)+(1*1)=130
130 % 10 = 0
So 14678-81-0 is a valid CAS Registry Number.
14678-81-0Relevant articles and documents
Synthesis of Some Benzimidazole-based Heterocycles and their Application as Copper Corrosion Inhibitors
Eldebss, Taha M. A.,Farag, Ahmad M.,Shamy, Adel Y. M.
, p. 371 - 390 (2019)
A series of new substituted benzimidazoles embedded with a variety of function groups has been synthesized from N-methyl-2-bromoacetylbenzimidazole. The synthesized compounds were fully characterized, and their structures were elucidated based on elemental analysis, spectral data, and alternative synthetic pathways, whenever possible. Some of benzimidazole derivatives were tested as corrosion inhibitors.
DISILYLATED COMPOUNDS AS PRECURSORS OF HETEROCYCLES: SYNTHESIS OF BENZIMIDAZOLES, TRIAZOLES, FURAN AND PYRROLE.
Rigo, Benoit,Valligny, Dominique,Taisne, Sophie
, p. 167 - 180 (2007/10/02)
The cyclization of disilylated compounds catalyzed by trifluoromethanesulfonoc acid is an easy way to obtain some heterocycles such as benzimidazole, triazole, furan and pyrrole.
