146794-70-9 Usage
Description
(6R-trans)-7-[(2,2-dimethyl-1-oxopropyl)amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2is a complex organic compound with a unique molecular structure. It is characterized by its bicyclic ring system, which includes a five-membered thiazole ring and a four-membered azetidine ring. The compound also features a 2-ene-2group, a 3-methyl group, and a 7-amino group attached to a 2,2-dimethyl-1-oxopropyl group. This intricate structure suggests potential applications in various fields, particularly in the pharmaceutical and chemical industries.
Uses
1. Used in Pharmaceutical Industry:
(6R-trans)-7-[(2,2-dimethyl-1-oxopropyl)amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2is used as an intermediate compound for the synthesis of semi-synthetic antibiotics. Its unique structure allows it to be a key component in the development of new drugs with improved properties, such as enhanced efficacy, reduced side effects, or targeted delivery.
2. Used in Chemical Research:
(6R-trans)-7-[(2,2-diMethyl-1-oxopropyl)aMino]-3-Methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2is also used as a research tool in the field of organic chemistry. Its complex structure and various functional groups make it an interesting subject for studying reaction mechanisms, exploring new synthetic routes, and understanding the relationship between molecular structure and biological activity.
3. Used in Quality Control and Impurity Profiling:
As an impurity of the semi-synthetic antibiotic Cephalexin (C256800) and its hydroxy analogue Cefadroxil (C235750), (6R-trans)-7-[(2,2-dimethyl-1-oxopropyl)amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2is used in quality control and impurity profiling. Understanding and controlling the presence of this impurity in the final drug product is crucial for ensuring safety, efficacy, and regulatory compliance.
Check Digit Verification of cas no
The CAS Registry Mumber 146794-70-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,7,9 and 4 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 146794-70:
(8*1)+(7*4)+(6*6)+(5*7)+(4*9)+(3*4)+(2*7)+(1*0)=169
169 % 10 = 9
So 146794-70-9 is a valid CAS Registry Number.
146794-70-9Relevant articles and documents
Synthesis method of cefalexin impurity
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Paragraph 0035; 0037; 0041-0042; 0043; 0047-0048; 0049, (2019/07/01)
The invention provides a synthesis method of a cefalexin impurity. The method comprises the following steps: a, reacting 7-amino deacetoxy cephalosporanic acid with tetramethyl guanidine to obtain a 7-amino deacetoxyl cephalosporanic acid salt; b, carrying out reaction on the 7-amino deacetoxyl cephalosporanic acid salt and pivaloyl chloride to obtain (6R,7R)-7-[(2, 2-dimethyl-1-oxopropyl) amino ]-3-methyl-8-oxo-5-thio-1-azadicyclo [4.2.0] octyl-2-ene 2-carboxylic acid salt; and c, fully mixing dilute hydrochloric acid with a product obtained in the step b to carry out a hydrolysis reaction, standing for layering after the reaction is ended, taking an organic phase at the lower layer, and evaporating and crystallizing the obtained organic phase under reduced pressure so as to obtain the cefalexin impurity. The synthesis method can be used for synthesizing the cefalexin impurity, and has a great promotion effect on deeper and wider researches on cefalexin-related application safety, reliability and stability and quality control in the production process.
