146801-38-9

Basic information

• Product Name: 2-Buten-1-one, 4,4,4-trifluoro-1,3-diphenyl-, (2E)-
• Synonyms: 2-Buten-1-one,4,4,4-trifluoro-1,3-diphenyl
• CAS NO: 146801-38-9
• Molecular Formula: C16H11F3O
• Molecular Weight: 276.258
• Mol File: 146801-38-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 359.4±42.0 °C(Predicted)
• Density: 1?+-.0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-Buten-1-one, 4,4,4-trifluoro-1,3-diphenyl-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Buten-1-one, 4,4,4-trifluoro-1,3-diphenyl-, (2E)-(146801-38-9)
• EPA Substance Registry System: 2-Buten-1-one, 4,4,4-trifluoro-1,3-diphenyl-, (2E)-(146801-38-9)

Safety Data

• Hazardous Substances Data: 146801-38-9(Hazardous Substances Data)

Upstream product

• 6919-61-5 N-methoxy-N-methylbenzamide 
• 146801-19-6 4,4,4-trifluoro-3-hydroxy-1,3-diphenyl-1-butanone 
• 93-89-0 benzoic acid ethyl ester 
• 383-63-1 ethyl trifluoroacetate, 
• 1015-28-7 dimethyl (2-oxo-2-phenylethyl)phosphonate 
• 100-58-3 phenylmagnesium bromide 
• 434-45-7 2,2,2-Trifluoroacetophenone 
• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 
• 283584-96-3 (E)-1,3-diphenyl-3-trifluoromethylprop-2-en-1-ol 
• 3282-32-4 2-diazo-acetophenone 
• 6048-29-9 triphenylphenacylphosphonium bromide 
• 62-53-3 aniline 
• 500719-87-9 4,4,4-trifluoro-1-(N-methoxy-N-methylamino)-1-phenyl-1-(trimethylsiloxyl)-2-butyne 
• 1678-18-8 (2-oxo-2-phenylethyl)-triphenylphosphonium chloride 

Downstream Products

• 1333232-27-1 5-(trifluoromethyl)-4,5-dihydro-3,5-diphenylisoxazole 
• 1245905-57-0 (R)-5-(trifluoromethyl)-4,5-dihydro-3,5-diphenylisoxazole 
• 1245905-75-2 (S)-5-(trifluoromethyl)-4,5-dihydro-3,5-diphenylisoxazole 
• 1245905-93-4 (E)-4,4,4-trifluoro-1,3-diphenylbut-2-en-1-one oxime 
• 283584-96-3 (R)-(E)-4,4,4-trifluoro-1,3-diphenyl-2-buten-1-ol 
• 1020171-83-8 (R)-4,4,4-trifluoro-1,3-diphenylbutan-1-one 
• 1392505-17-7 (E)-4,4,4-trifluoro-1,3-diphenyl(1-D)-2-buten-1-ol 
• 1392505-46-2 4,4,4-(E)-[3-D]-4,4,4-trifluoro-1,3-diphenylbutan-1-one 
• 1452160-05-2 (R)-4,4,4-trifluoro-3-(nitromethyl)-1,3-diphenylbutan-1-one 
• 1452160-23-4 (R)-3,5-diphenyl-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrole 1-oxide 

Relevant articles and documents

Copper-Catalyzed Aldol Reaction of Vinyl Azides with Trifluoromethyl Ketones

A novel and efficient aldol reaction of readily available vinyl azides with trifluoromethyl ketones by copper catalysis is developed. The reaction is proposed to go through a nucleophilic trapping of vinyl azides with trifluoromethyl ketones as a trifluor

Base-promoted isomerization of CF3-containing allylic alcohols to the corresponding saturated ketones under metal-free conditions

Following to the computational expectation, our previously reported intriguing 1,3-proton shift of 4,4,4-trifluorobut-2-yn-1-ols was successfully extended to the 4,4,4-trifluorobut-2-en-1-ol system under metal-free conditions to afford the corresponding saturated ketones in high to excellent chemical yields using such a convenient and easy-to-handle base as DBU at the toluene refluxing temperature, and utilization of the corresponding optically active substrates unambiguously demonstrated that this transformation proceeded in a highly stereoselective fashion.

Efficient and highly enantioselective construction of trifluoromethylated quaternary stereogenic centers via high-pressure mediated organocatalytic conjugate addition of nitromethane to β,β-disubstituted enones

A very effective high-pressure-induced acceleration of asymmetric organocatalytic conjugate addition of nitromethane to sterically congested β,β-disubstituted β-CF3 enones has been developed. A combination of pressure (8-10 kbar) and noncovalent catalysis with low-loading of chiral tertiary amine-thioureas (0.5-3 mol %) is shown to provide very efficient access to a wide range of γ-nitroketones containing trifluoromethylated all-carbon quaternary stereogenic centers in the β-position (80-97%, 92-98% ee).