1469462-86-9

Basic information

• Product Name: 1-cyano-1-(3-nitrophenyl)ethyl diethyl phosphate
• Synonyms: 1-cyano-1-(3-nitrophenyl)ethyl diethyl phosphate
• CAS NO: 1469462-86-9
• Molecular Weight: 328.262
• Mol File: 1469462-86-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-cyano-1-(3-nitrophenyl)ethyl diethyl phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyano-1-(3-nitrophenyl)ethyl diethyl phosphate(1469462-86-9)
• EPA Substance Registry System: 1-cyano-1-(3-nitrophenyl)ethyl diethyl phosphate(1469462-86-9)

Safety Data

• Hazardous Substances Data: 1469462-86-9(Hazardous Substances Data)

Upstream product

• 2942-58-7 diethyl cyanophosphonate 
• 2408-36-8 lithium cyanide 
• 121-89-1 3-Nitroacetophenone 

Relevant articles and documents

Transformation of Carbonyl Compounds into Homologous Alkynes under Neutral Conditions: Fragmentation of Tetrazoles Derived from Cyanophosphates

Cyanophosphates (CPs) can be easily prepared from either ketones or aldehydes, and their reaction with NaN3-Et3N·HCl results in the formation of azidotetrazoles. Under microwave irradiation, successive fragmentation of the azidotetrazoles generates alkylidene carbenes that undergo [1,2]-rearrangement and are transformed into homologous alkynes. Treatment of ketone-derived CPs with TMSN3 and Bu2SnO as catalyst in toluene at reflux directly yields the corresponding internal alkynes, whereas the reaction of aldehyde-derived CPs with NaN3-Et3N·HCl in THF at reflux or TMSN3-Bu2SnO (cat.) in toluene at reflux provides homologous terminal alkynes in good yields. These reactions take place under neutral conditions and can be successfully extended to obtain alkynes that are not usually accessible from the corresponding carbonyl compounds by the Ohira-Bestmann or Shioiri procedures, which require basic conditions.