147-20-6 Usage
Description
Diphenylpyraline, also known as benzhydryl ether derivative of 1-methyl-4-hydroxypiperidine, is a member of the piperidine class. It is a sedating antihistamine with various applications in the medical field due to its ability to provide symptomatic relief for various conditions.
Uses
Used in Allergy Treatment:
Diphenylpyraline is used as a sedating antihistamine, particularly for the symptomatic relief of allergic conditions such as rhinitis and hay fever. It helps alleviate symptoms like sneezing, itching, and watery eyes by blocking the action of histamine, a substance released during an allergic reaction.
Used in Skin Disorder Treatment:
Diphenylpyraline is also utilized in the treatment of pruritic skin disorders, where it provides relief from itching and irritation. Its antihistamine properties help reduce inflammation and discomfort associated with various skin conditions.
Used in Cough and Cold Remedies:
Furthermore, diphenylpyraline is used as the teoclate salt (piprinhydrinate) in compound preparations for the symptomatic relief of coughs and the common cold. It helps suppress the cough reflex and provides temporary relief from the discomfort associated with coughing and cold symptoms.
Therapeutic Function
Antihistaminic
Check Digit Verification of cas no
The CAS Registry Mumber 147-20-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 7 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 147-20:
(5*1)+(4*4)+(3*7)+(2*2)+(1*0)=46
46 % 10 = 6
So 147-20-6 is a valid CAS Registry Number.
InChI:InChI=1/C19H23NO/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-19H,12-15H2,1H3
147-20-6Relevant articles and documents
Synthesis and biological evaluation of new N-substituted 4-(arylmethoxy)piperidines as dopamine transporter inhibitors
Lapa, Gennady B.,Lapa, Alla A.
, p. 203 - 205 (2019/04/25)
The library of new N-substituted 4-(arylmethoxy)piperidines as dopamine transporter inhibitors was designed and synthesized. H-Bond donors in piperidine ring were found to be important for reduced locomotor activity in mice. 4-[Bis(4-fluorophenyl)methoxy]piperidine has IC50 17.0 ± 1.0 nm for dopamine transporter and locomotor activity, which is lower than that for cocaine.